Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HMT-3522 T4-2 | Unknown | Unknown | CGC-11047 | Polyamine analogue | 0.064 | uM | 10147.034 | 1.0052 | 1.0044 | 2.3470 | ||
| SUM185PE | TNBC | Luminal | Glycyl-H-1152 | ROCK2 | 13.3 | uM | 12269.16 | 0.9220 | 0.7673 | 0.6567 | ||
| HMT-3522 T4-2 | Unknown | Unknown | CGC-11047 | Polyamine analogue | 0.0128 | uM | 10147.034 | 1.0468 | 1.0394 | 2.3470 | ||
| SUM185PE | TNBC | Luminal | Glycyl-H-1152 | ROCK2 | 0.107 | uM | 12269.16 | 0.7060 | 0.1771 | 0.6567 | ||
| HMT-3522 T4-2 | Unknown | Unknown | CGC-11047 | Polyamine analogue | 1.6 | uM | 10147.034 | 0.5975 | 0.6059 | 2.3470 | ||
| SUM185PE | TNBC | Luminal | Glycyl-H-1152 | ROCK2 | 0.0213 | uM | 12269.16 | 0.6741 | 0.0970 | 0.6567 | ||
| HMT-3522 T4-2 | Unknown | Unknown | CGC-11047 | Polyamine analogue | 40 | uM | 10147.034 | 0.6092 | 0.6192 | 2.3470 | ||
| MX1 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 0.107 | uM | 12220.16 | 0.9472 | 0.7685 | 0.4410 | ||
| HMT-3522 T4-2 | Unknown | Unknown | CGC-11047 | Polyamine analogue | 8 | uM | 10147.034 | 0.6222 | 0.6339 | 2.3470 | ||
| MX1 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 13.3 | uM | 12220.16 | 0.4324 | -0.7012 | 0.4410 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 7863.018 | 0.6219 | 0.5942 | 2.0946 | ||
| SUM185PE | TNBC | Luminal | Glycyl-H-1152 | ROCK2 | 0.533 | uM | 12269.16 | 0.4249 | -0.4568 | 0.6567 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7861.018 | 2.2654 | 4.2429 | 0.8485 | ||
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 0.267 | uM | 10579.138 | 1.0523 | 1.1062 | 0.9860 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 40 | uM | 7861.018 | 1.3344 | 1.8098 | 0.8485 | ||
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 0.000427 | uM | 10579.138 | 1.0488 | 1.0990 | 0.9860 | ||
| HMT-3522 T4-2 | Unknown | Unknown | CGC-11047 | Polyamine analogue | 5000 | uM | 10147.034 | 0.0099 | -0.7197 | 2.3470 | ||
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 0.0000853 | uM | 10579.138 | 1.0797 | 1.1617 | 0.9860 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 7861.018 | 2.1188 | 3.8454 | 0.8485 | ||
| SUM185PE | TNBC | Luminal | Glycyl-H-1152 | ROCK2 | 66.7 | uM | 12269.16 | 0.7108 | 0.1892 | 0.6567 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 7861.018 | 1.3156 | 1.7631 | 0.8485 | ||
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 0.0533 | uM | 10579.138 | 0.9342 | 0.8667 | 0.9860 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 7861.018 | 1.3382 | 1.8193 | 0.8485 | ||
| SUM225CWN | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 0.00213 | uM | 10579.138 | 1.0226 | 1.0458 | 0.9860 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 7861.018 | 1.3637 | 1.8828 | 0.8485 |