Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 7870.001 | 0.3899 | 0.2689 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 9551.001 | 1.0342 | 1.0252 | 2.6913 | |
| MCF 10A | NM | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 7870.001 | 1.0149 | 1.0144 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 7870.001 | 0.9982 | 0.9982 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 7870.001 | 0.9983 | 0.9983 | 2.0700 | |
| LY2 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 10264.001 | 0.0485 | -0.7214 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 10264.001 | 0.7928 | 0.7193 | 1.5356 | |
| MCF 10A | NM | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7870.001 | 0.9879 | 0.9882 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 7870.001 | 0.7439 | 0.7337 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 9551.001 | 1.0229 | 1.0169 | 2.6913 | |
| LY2 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 10264.001 | 0.8916 | 0.8560 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 10264.001 | 1.0160 | 1.0208 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 10264.001 | 0.9906 | 0.9878 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 10264.001 | 1.0457 | 1.0591 | 1.5356 | |
| Hs 578T | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 9511.001 | 0.0050 | -0.9784 | 1.1698 | |
| LY2 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 10264.001 | 0.9968 | 0.9958 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 10264.001 | 0.9470 | 0.9303 | 1.5356 | |
| Hs 578T | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 9511.001 | 0.7932 | 0.6406 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 9511.001 | 0.8316 | 0.7084 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 9511.001 | 0.5217 | 0.1469 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 9511.001 | 1.0273 | 1.0466 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 9511.001 | 1.0261 | 1.0446 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 9511.001 | 0.8732 | 0.7812 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 9511.001 | 0.3602 | -0.1646 | 1.1698 | |
| LY2 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 10264.001 | 0.9649 | 0.9540 | 1.5356 |