Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 10996.143 | 0.9593 | 0.7440 | 0.3034 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 10996.143 | 0.9653 | 0.7805 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 10996.143 | 0.9585 | 0.7390 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Ibandronate | FDPS | 0.48 | uM | 10996.143 | 0.9914 | 0.9437 | 0.3034 | ||
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9913.001 | 0.2335 | -0.9831 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9913.001 | 1.1767 | 2.4115 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9913.001 | 0.9993 | 0.9957 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9913.001 | 1.2038 | 2.6765 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9913.001 | 1.0381 | 1.2610 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9913.001 | 1.1702 | 2.3501 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9913.001 | 1.1961 | 2.5993 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9913.001 | 1.0525 | 1.3660 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9913.001 | 1.0368 | 1.2520 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9913.001 | 0.7093 | -0.3520 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9913.001 | 1.1080 | 1.8001 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9913.001 | 0.6981 | -0.3852 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9913.001 | 0.6137 | -0.5971 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9913.001 | 1.1543 | 2.2028 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9913.001 | 0.9083 | 0.4587 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9913.001 | 1.0773 | 1.5535 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9913.001 | 1.0439 | 1.3030 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9913.001 | 0.6652 | -0.4752 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9913.001 | 1.0883 | 1.6398 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9913.001 | 1.0842 | 1.6080 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9913.001 | 0.9017 | 0.4239 | 0.3047 |