Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 8 | uM | 10579.143 | 1.0865 | 1.2281 | 0.7678 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 33.3 | uM | 10442.066 | 0.6767 | 0.5789 | 1.6519 | |
| SUM225CWN | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 1.6 | uM | 10579.143 | 0.9643 | 0.9074 | 0.7678 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.000427 | uM | 7454.066 | 0.7734 | 0.6348 | 1.2748 | |
| SUM225CWN | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 1000 | uM | 10579.143 | 0.6568 | 0.1567 | 0.7678 | |
| SUM225CWN | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 0.064 | uM | 12098.143 | 1.0990 | 1.2018 | 0.9820 | |
| SUM225CWN | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 200 | uM | 10579.143 | 0.8766 | 0.6848 | 0.7678 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 1.33 | uM | 7454.066 | 0.8240 | 0.7182 | 1.2748 | |
| SUM225CWN | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 12098.143 | 0.9985 | 0.9968 | 0.9820 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7455.066 | 1.0109 | 1.0168 | 1.2976 | |
| SUM225CWN | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 5000 | uM | 10579.143 | 0.4109 | -0.3720 | 0.7678 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.00213 | uM | 7455.066 | 0.9142 | 0.8664 | 1.2976 | |
| SUM225CWN | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 40 | uM | 12098.143 | 0.8708 | 0.7371 | 0.9820 | |
| MDA-MB-361 | HER2amp | Luminal | 2-deoxyglucose | 0.213 | uM | 12989.177 | 1.0421 | 1.2312 | 0.3765 | |||
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.000427 | uM | 7456.066 | 1.0189 | 1.0211 | 1.7785 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 6.67 | uM | 7456.066 | 0.8531 | 0.8291 | 1.7785 | |
| SUM225CWN | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 8 | uM | 12098.143 | 0.9805 | 0.9602 | 0.9820 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7456.066 | 1.0178 | 1.0199 | 1.7785 | |
| MDA-MB-361 | HER2amp | Luminal | 2-deoxyglucose | 1.07 | uM | 12989.177 | 0.7334 | -0.1223 | 0.3765 | |||
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 0.000427 | uM | 7455.072 | 0.9662 | 0.9434 | 1.1966 | |
| SUM225CWN | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 1000 | uM | 12098.143 | 0.5756 | 0.1397 | 0.9820 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.0107 | uM | 7456.066 | 1.0597 | 1.0663 | 1.7785 | |
| SUM225CWN | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 200 | uM | 12098.143 | 0.7327 | 0.4570 | 0.9820 | |
| BT-474 | HER2amp | Luminal | Bosutinib | Src | nRTK | 33.3 | uM | 12291.17 | 0.4215 | -0.5742 | 0.5585 | |
| BT-474 | HER2amp | Luminal | Bosutinib | Src | nRTK | 6.67 | uM | 12291.17 | 0.4573 | -0.5072 | 0.5585 |