Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Etoposide | TOP2 | TOP | 0.000853 | uM | 7533.074 | 1.0097 | 1.0183 | 1.0648 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 1.33 | uM | 7841.016 | 0.8296 | 0.3196 | 0.4493 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 1.33 | uM | 7894.016 | 0.9423 | 0.8524 | 0.7753 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 7841.016 | 0.6548 | -0.2207 | 0.4493 | |
| AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7793.007 | 0.0056 | -0.9529 | 1.3832 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7793.001 | 1.0877 | 1.1516 | 1.1508 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.00213 | uM | 7894.016 | 1.0165 | 1.0427 | 0.7753 | |
| MDA-MB-361 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 0.00213 | uM | 10643.138 | 1.0476 | 1.1957 | 0.4981 | ||
| BT-474 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 0.533 | uM | 12291.156 | 0.6636 | 0.0004 | 0.5920 | |
| MDA-MB-361 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 0.0107 | uM | 10643.138 | 1.0534 | 1.2202 | 0.4981 | ||
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 7894.016 | 0.9891 | 0.9719 | 0.7753 | |
| MDA-MB-361 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 0.000171 | uM | 12379.169 | 0.9988 | 0.9959 | 0.5957 | ||
| BT-474 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 0.107 | uM | 12291.156 | 0.6372 | -0.0659 | 0.5920 | |
| MDA-MB-361 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 0.000427 | uM | 10999.15 | 1.0365 | 1.0925 | 0.7928 | ||
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.267 | uM | 7894.016 | 0.9607 | 0.8993 | 0.7753 | |
| MDA-MB-361 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 6.67 | uM | 10643.138 | 0.8718 | 0.5185 | 0.4981 | ||
| HCC202 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 66.7 | uM | 7458.091 | 0.6553 | -0.0727 | 0.5499 | |
| MDA-MB-361 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 0.267 | uM | 10643.138 | 1.1393 | 1.5988 | 0.4981 | ||
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0107 | uM | 7894.016 | 0.9886 | 0.9705 | 0.7753 | |
| MDA-MB-361 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 1.33 | uM | 10643.138 | 1.0299 | 1.1219 | 0.4981 | ||
| AU565 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 0.000171 | uM | 10880.156 | 1.0702 | 1.0908 | 1.5288 | |
| MDA-MB-361 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 0.0000853 | uM | 10999.15 | 0.9351 | 0.8376 | 0.7928 | ||
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 7894.016 | 0.9753 | 0.9365 | 0.7753 | |
| MDA-MB-361 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 33.3 | uM | 10643.138 | 0.8069 | 0.3000 | 0.4981 | ||
| BT-474 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 0.0213 | uM | 12291.156 | 0.7280 | 0.1700 | 0.5920 |