Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7896.001 | 0.5704 | 0.2484 | 1.1912 | |
| AU565 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 2.67 | uM | 5900.093 | 0.7608 | 0.7767 | 2.3084 | |
| MDA-MB-361 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 0.000853 | uM | 12379.167 | 1.0496 | 1.1949 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | Mebendazole | 0.000853 | uM | 12989.174 | 0.9310 | 0.8079 | 0.7084 | |||
| AU565 | HER2amp | Luminal | IKK16 | IKK | NFKB | 66.7 | uM | 5900.093 | 0.0063 | -0.7771 | 2.3084 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7793.036 | 0.9708 | 0.9455 | 1.0741 | |
| MDA-MB-361 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 66.7 | uM | 12379.167 | 0.9196 | 0.7027 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | Mebendazole | 0.000171 | uM | 12989.174 | 0.9855 | 0.9592 | 0.7084 | |||
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7820.001 | 0.9566 | 0.8879 | 0.7692 | |
| SUM44PE | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7538.05 | 0.7270 | 0.1304 | 0.5587 | |
| MDA-MB-361 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 13.3 | uM | 12379.167 | 0.9466 | 0.8000 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 0.064 | uM | 12379.168 | 1.0073 | 1.0316 | 0.4672 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10095.001 | 0.9666 | 0.9262 | 0.9049 | |
| SUM44PE | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7538.05 | 0.7042 | 0.0675 | 0.5587 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9648.001 | 1.0326 | 1.1047 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | Mebendazole | 0.107 | uM | 12989.174 | 0.9340 | 0.8163 | 0.7084 | |||
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9648.001 | 0.5150 | -0.3037 | 0.6289 | |
| SUM44PE | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7538.05 | 1.0010 | 1.0034 | 0.5587 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9163.011 | 1.0268 | 1.0861 | 0.6266 | |
| MDA-MB-361 | HER2amp | Luminal | Mebendazole | 0.00427 | uM | 12989.174 | 0.9586 | 0.8840 | 0.7084 | |||
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7819.001 | 0.8918 | 0.5847 | 0.4919 | |
| SUM44PE | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7538.05 | 0.7670 | 0.2440 | 0.5587 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 13.1 | uM | 9146.12 | 0.1389 | -0.6602 | 1.1135 | |
| MDA-MB-361 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 0.000512 | uM | 12379.168 | 1.0557 | 1.2459 | 0.4672 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9648.001 | 0.5048 | -0.3256 | 0.6289 |