Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | 2-deoxyglucose | 3330 | uM | 12989.177 | 0.8271 | 0.2081 | 0.3765 | |||
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 167 | uM | 10469.072 | 0.6680 | 0.4813 | 1.3439 | |
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 0.0533 | uM | 11055.072 | 0.9313 | 0.9224 | 1.7997 | |
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 0.267 | uM | 11055.072 | 0.9253 | 0.9155 | 1.7997 | |
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 6.67 | uM | 11055.072 | 0.9579 | 0.9528 | 1.7997 | |
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 33.3 | uM | 11055.072 | 0.9556 | 0.9501 | 1.7997 | |
| HCC202 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.00213 | uM | 10470.072 | 1.0000 | 1.0000 | 0.3299 | |
| HCC202 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.0107 | uM | 10470.072 | 1.0094 | 1.0576 | 0.3299 | |
| HCC202 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.267 | uM | 10470.072 | 1.0077 | 1.0471 | 0.3299 | |
| HCC202 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 1.33 | uM | 10470.072 | 0.9689 | 0.8175 | 0.3299 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.00213 | uM | 7506.073 | 1.0014 | 1.0028 | 0.9958 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.0107 | uM | 7506.073 | 0.9778 | 0.9555 | 0.9958 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 1.23 | uM | 7793.035 | 0.7495 | 0.5765 | 1.2119 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.267 | uM | 7506.073 | 0.9970 | 0.9940 | 0.9958 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 33.3 | uM | 7506.073 | 1.0850 | 1.1708 | 0.9958 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 167 | uM | 7506.073 | 0.8671 | 0.7332 | 0.9958 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.00213 | uM | 10472.072 | 1.0109 | 1.0357 | 0.6135 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.0107 | uM | 10472.072 | 0.9850 | 0.9513 | 0.6135 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 0.246 | uM | 7793.035 | 0.8825 | 0.8040 | 1.2119 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 6.67 | uM | 10472.072 | 1.0034 | 1.0111 | 0.6135 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 167 | uM | 10472.072 | 0.8744 | 0.6069 | 0.6135 | |
| MDA-MB-361 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.000427 | uM | 10643.072 | 1.0501 | 1.1662 | 0.6128 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 0.0492 | uM | 7793.035 | 1.0337 | 1.0554 | 1.2119 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.0533 | uM | 12379.17 | 1.0833 | 1.2956 | 0.5805 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.0107 | uM | 12379.17 | 1.0259 | 1.0902 | 0.5805 |