Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.000427 | uM | 7457.066 | 0.8894 | 0.8637 | 1.6601 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 10580.143 | 0.8992 | 0.7624 | 0.8402 | |
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 0.00213 | uM | 10469.072 | 1.0535 | 1.0792 | 1.3439 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 10754.143 | 0.9238 | 0.8729 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 200 | uM | 10754.143 | 0.6083 | 0.3249 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 10580.143 | 0.4635 | -0.1992 | 0.8402 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 6.67 | uM | 7457.066 | 0.8709 | 0.8402 | 1.6601 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 40 | uM | 10754.143 | 0.7084 | 0.5032 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 10754.143 | 0.9017 | 0.8357 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.32 | uM | 10754.143 | 0.8806 | 0.8000 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 1.6 | uM | 10754.143 | 1.0470 | 1.0776 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 10754.143 | 0.3059 | -0.2503 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 1000 | uM | 10754.143 | 0.4296 | -0.0068 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 11938.143 | 1.0134 | 1.0513 | 0.5258 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 11938.143 | 0.9856 | 0.9455 | 0.5258 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 40 | uM | 11938.143 | 0.7283 | 0.0943 | 0.5258 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 11938.143 | 0.7869 | 0.2677 | 0.5258 | |
| MDA-MB-361 | HER2amp | Luminal | 2-deoxyglucose | 0.00853 | uM | 12989.177 | 1.0118 | 1.0635 | 0.3765 | |||
| MDA-MB-361 | HER2amp | Luminal | 2-deoxyglucose | 0.0427 | uM | 12989.177 | 0.8424 | 0.2684 | 0.3765 | |||
| MDA-MB-361 | HER2amp | Luminal | 2-deoxyglucose | 0.213 | uM | 12989.177 | 1.0421 | 1.2312 | 0.3765 | |||
| MDA-MB-361 | HER2amp | Luminal | 2-deoxyglucose | 1.07 | uM | 12989.177 | 0.7334 | -0.1223 | 0.3765 | |||
| MDA-MB-361 | HER2amp | Luminal | 2-deoxyglucose | 5.33 | uM | 12989.177 | 1.0073 | 1.0391 | 0.3765 | |||
| MDA-MB-361 | HER2amp | Luminal | 2-deoxyglucose | 26.7 | uM | 12989.177 | 1.0156 | 1.0841 | 0.3765 | |||
| HCC1954 | HER2amp | Basal A | Bosutinib | Src | nRTK | 4 | uM | 11055.145 | 0.4342 | 0.2455 | 1.7616 | |
| HCC1954 | HER2amp | Basal A | Bosutinib | Src | nRTK | 0.8 | uM | 11055.145 | 0.6277 | 0.5354 | 1.7616 |