Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7555.065 | 0.9695 | 0.9650 | 1.7561 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 13.3 | uM | 11939.158 | 0.0171 | -0.8106 | 1.7251 | |
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7555.065 | 0.8916 | 0.8735 | 1.7561 | |
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9972.125 | 1.0703 | 1.1180 | 1.1854 | ||
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7555.065 | 0.2133 | -0.1704 | 1.7561 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 2.67 | uM | 11939.158 | 0.6938 | 0.6180 | 1.7251 | |
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7555.065 | 0.0784 | -0.5309 | 1.7561 | |
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 9972.125 | 0.8979 | 0.8263 | 1.1854 | ||
| ZR75B | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.0213 | uM | 14149.189 | 0.9310 | 0.9358 | 2.1888 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.000853 | uM | 11939.158 | 0.8974 | 0.8783 | 1.7251 | |
| ZR75B | HR+ | Luminal | XRP44X | ELK3 | MAPK | 133 | uM | 11939.157 | 0.4625 | 0.2317 | 1.5908 | |
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 9972.125 | 0.6322 | 0.3584 | 1.1854 | ||
| ZR75B | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.00427 | uM | 14149.189 | 0.9329 | 0.9375 | 2.1888 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.000171 | uM | 11939.158 | 0.9172 | 0.9022 | 1.7251 | |
| ZR75B | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000853 | uM | 14149.189 | 0.9082 | 0.9139 | 2.1888 | |
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 9972.125 | 0.8038 | 0.6635 | 1.1854 | ||
| ZR75B | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000171 | uM | 14149.189 | 0.9458 | 0.9497 | 2.1888 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.533 | uM | 11939.158 | 0.9007 | 0.8824 | 1.7251 | |
| ZR75B | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.533 | uM | 14149.189 | 0.9268 | 0.9317 | 2.1888 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9972.121 | 1.0705 | 1.1274 | 1.1034 | |
| ZR75B | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 13.3 | uM | 14149.189 | 0.2554 | 0.0720 | 2.1888 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.00427 | uM | 11939.158 | 0.8877 | 0.8666 | 1.7251 | |
| ZR75B | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 2.67 | uM | 14149.189 | 0.6058 | 0.5906 | 2.1888 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9972.121 | 1.0018 | 1.0032 | 1.1034 | |
| ZR75B | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 66.7 | uM | 14149.189 | 0.1528 | -0.1522 | 2.1888 |