Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 5898.095 | 0.7260 | 0.2638 | 0.6975 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 5898.095 | 0.7530 | 0.3316 | 0.6975 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 5898.095 | 0.7469 | 0.3163 | 0.6975 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 5898.095 | 0.7435 | 0.3076 | 0.6975 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 5898.095 | 0.7991 | 0.4501 | 0.6975 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 5894.095 | 0.9508 | 0.9420 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 5894.095 | 0.9978 | 0.9974 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 5894.095 | 1.0198 | 1.0230 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 5894.095 | 0.7840 | 0.7352 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 5894.095 | 0.2174 | -0.1792 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 5894.095 | 0.3330 | 0.0526 | 1.7133 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 5895.095 | 0.9618 | 0.9475 | 1.4629 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.187 | uM | 5895.095 | 0.8564 | 0.7989 | 1.4629 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 117 | uM | 5895.095 | 0.3334 | -0.0561 | 1.4629 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 5895.095 | 0.3541 | -0.0165 | 1.4629 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.00749 | uM | 5896.095 | 0.9589 | 0.9467 | 1.5532 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.0374 | uM | 5896.095 | 0.9593 | 0.9472 | 1.5532 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 5896.095 | 0.2340 | -0.2149 | 1.5532 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 5896.095 | 0.1870 | -0.3204 | 1.5532 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 585 | uM | 5896.095 | 0.2029 | -0.2838 | 1.5532 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 2920 | uM | 5896.095 | 0.2453 | -0.1907 | 1.5532 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 5897.095 | 0.2952 | -0.2645 | 1.2197 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 23.4 | uM | 5897.095 | 0.2640 | -0.3288 | 1.2197 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 4.68 | uM | 5899.094 | 1.0058 | 1.0112 | 1.0334 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 0.936 | uM | 5899.094 | 1.0319 | 1.0618 | 1.0334 |