Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 10267.026 | 1.3001 | 3.6322 | 0.3125 | |
| UACC-893 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 9045.018 | 1.0992 | 1.1829 | 1.0807 | |
| ZR75B | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 9997.026 | 1.0393 | 1.0691 | 1.1348 | |
| HCC1395 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 9258.026 | 1.0592 | 1.2149 | 0.5632 | |
| HCC1569 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7447.102 | 0.9794 | 0.9748 | 1.6467 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7898.018 | 1.0605 | 1.1069 | 1.1279 | |
| HCC1569 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7824.018 | 1.1632 | 1.2443 | 1.3115 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7793.018 | 0.9841 | 0.9758 | 1.3186 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7794.018 | 1.4026 | 1.4458 | 1.6812 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 9035.018 | 0.9639 | 0.9662 | 2.1555 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7899.018 | 1.0968 | 1.0925 | 2.0432 | |
| MDA-MB-468 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7904.018 | 1.1285 | 1.1796 | 1.4056 | |
| MDA-MB-468 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7906.018 | 0.6874 | 0.3239 | 0.9087 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 9146.122 | 1.0961 | 1.1417 | 1.3408 | |
| HCC70 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 9501.026 | 1.1286 | 1.3443 | 0.7616 | |
| BT-474 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 9158.123 | 1.0016 | 1.0036 | 0.8769 | |
| HCC1569 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 9347.026 | 1.1178 | 1.1793 | 1.2965 | |
| MDA-MB-231 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7892.018 | 0.9890 | 0.9911 | 2.4903 | |
| BT-20 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 5903.102 | 1.0353 | 1.0560 | 1.2557 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7900.018 | 0.8675 | 0.6853 | 0.8304 | |
| HMT-3522 S1 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7911.018 | 0.9903 | 0.9895 | 1.8543 | |
| BT-474 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7798.018 | 1.0380 | 1.0522 | 1.4461 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7902.018 | 1.4257 | 1.4180 | 1.8686 | |
| Hs 578T | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7861.018 | 2.1567 | 3.9477 | 0.8485 | |
| MCF12A | NM | Basal B | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 10061.123 | 0.9962 | 0.9960 | 1.9064 |