Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 0.064 | uM | 10581.143 | 0.8607 | 0.6948 | 0.9062 | |
| BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 8 | uM | 10581.143 | 1.0124 | 1.0273 | 0.9062 | |
| BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 40 | uM | 10581.143 | 0.8364 | 0.6422 | 0.9062 | |
| BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 1000 | uM | 10581.143 | 0.5903 | 0.1180 | 0.9062 | |
| BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 5000 | uM | 10581.143 | 0.4492 | -0.1731 | 0.9062 | |
| 184A1 | NM | Basal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 12509.143 | 1.0576 | 1.0853 | 1.3392 | |
| 184A1 | NM | Basal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 12509.143 | 1.0070 | 1.0104 | 1.3392 | |
| 184A1 | NM | Basal | 5-DFUR | TYMS | TYMS | 1.6 | uM | 12509.143 | 1.0174 | 1.0259 | 1.3392 | |
| 184A1 | NM | Basal | 5-DFUR | TYMS | TYMS | 8 | uM | 12509.143 | 0.9222 | 0.8826 | 1.3392 | |
| 184A1 | NM | Basal | 5-DFUR | TYMS | TYMS | 1000 | uM | 12509.143 | 0.5790 | 0.3300 | 1.3392 | |
| 184A1 | NM | Basal | 5-DFUR | TYMS | TYMS | 5000 | uM | 12509.143 | 0.2735 | -0.2404 | 1.3392 | |
| 184B5 | NM | Basal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 12566.143 | 0.9531 | 0.9423 | 1.6413 | |
| 184B5 | NM | Basal | 5-DFUR | TYMS | TYMS | 0.32 | uM | 12566.143 | 0.9628 | 0.9543 | 1.6413 | |
| 184B5 | NM | Basal | 5-DFUR | TYMS | TYMS | 200 | uM | 12566.143 | 0.6535 | 0.5433 | 1.6413 | |
| 184B5 | NM | Basal | 5-DFUR | TYMS | TYMS | 1000 | uM | 12566.143 | 0.5604 | 0.4053 | 1.6413 | |
| 600MPE | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 12224.143 | 0.9826 | 0.9584 | 0.8349 | |
| 600MPE | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 12224.143 | 0.9673 | 0.9220 | 0.8349 | |
| 600MPE | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 12224.143 | 0.6358 | 0.1626 | 0.8349 | |
| 600MPE | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 40 | uM | 12224.143 | 0.6315 | 0.1533 | 0.8349 | |
| 600MPE | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 1000 | uM | 12224.143 | 0.5729 | 0.0262 | 0.8349 | |
| 600MPE | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 12224.143 | 0.3844 | -0.3636 | 0.8349 | |
| AU565 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 10880.143 | 0.5299 | 0.3474 | 1.6077 | |
| AU565 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 40 | uM | 10880.143 | 0.5619 | 0.3973 | 1.6077 | |
| BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 8 | uM | 11854.143 | 0.9550 | 0.9193 | 1.1185 | |
| BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 1.6 | uM | 11854.143 | 0.9707 | 0.9475 | 1.1185 |