Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HBL-100 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.000427 | uM | 7429.066 | 0.9946 | 0.9954 | 2.3904 | |
| HMT-3522 S1 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.000221 | uM | 10124.034 | 1.4272 | 1.3410 | 2.2594 | |
| HMT-3522 S1 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.0011 | uM | 10124.034 | 1.0212 | 1.0187 | 2.2594 | |
| HMT-3522 S1 | Unknown | Unknown | 5-FU | TYMS | TYMS | 30.7 | uM | 7911.017 | 0.8009 | 0.7432 | 1.6151 | |
| HBL-100 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.0533 | uM | 7429.066 | 0.9736 | 0.9778 | 2.3904 | |
| HMT-3522 S1 | Unknown | Unknown | 5-FU | TYMS | TYMS | 769 | uM | 7911.017 | 0.4073 | 0.1468 | 1.6151 | |
| HMT-3522 S1 | Unknown | Unknown | 5-FU | TYMS | TYMS | 6.15 | uM | 7911.017 | 0.8131 | 0.7595 | 1.6151 | |
| HMT-3522 S1 | Unknown | Unknown | 5-FU | TYMS | TYMS | 154 | uM | 7911.017 | 0.7262 | 0.6406 | 1.6151 | |
| HMT-3522 S1 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 86.2 | uM | 10124.034 | 0.0040 | -0.8261 | 2.2594 | |
| HMT-3522 T4-2 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.0011 | uM | 10147.034 | 1.1923 | 1.1556 | 2.3470 | |
| HMT-3522 T4-2 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.00552 | uM | 10147.034 | 1.0620 | 1.0519 | 2.3470 | |
| HBL-100 | Unknown | Unknown | AG1024 | IGF1R | RTK | 1.33 | uM | 7429.066 | 0.9746 | 0.9786 | 2.3904 | |
| HMT-3522 T4-2 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 3.45 | uM | 10147.034 | 0.0080 | -0.7445 | 2.3470 | |
| HMT-3522 T4-2 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 86.2 | uM | 10147.034 | 0.0012 | -0.8841 | 2.3470 | |
| MB 157 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9039.078 | 1.0011 | 1.0035 | 0.6306 | |
| HBL-100 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.267 | uM | 7429.066 | 0.9585 | 0.9648 | 2.3904 | |
| MB 157 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9039.078 | 0.9059 | 0.7100 | 0.6306 | |
| HMT-3522 S1 | Unknown | Unknown | 5-FU | TYMS | TYMS | 19200 | uM | 7911.017 | 0.1408 | -0.4058 | 1.6151 | |
| HMT-3522 S1 | Unknown | Unknown | 5-FU | TYMS | TYMS | 3840 | uM | 7911.017 | 0.2100 | -0.2389 | 1.6151 | |
| HBL-100 | Unknown | Unknown | Epirubicin | TOP2 | TOP | 0.011 | uM | 7807.017 | 1.0060 | 1.0054 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7807.017 | 0.9102 | 0.9163 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Epirubicin | TOP2 | TOP | 1.38 | uM | 7807.017 | 0.0080 | -0.7772 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Epirubicin | TOP2 | TOP | 6.9 | uM | 7807.017 | 0.0083 | -0.7730 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7429.066 | 0.9741 | 0.9781 | 2.3904 | |
| HBL-100 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7429.066 | 0.9761 | 0.9799 | 2.3904 |