Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.00252 | uM | 7552.095 | 0.9926 | 0.9867 | 1.1106 | |
| ZR-75-1 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 11660.146 | 0.8901 | 0.7735 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.276 | uM | 7931.017 | 0.7080 | 0.5483 | 1.3488 | |
| ZR-75-1 | HR+ | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 11660.146 | 0.7405 | 0.4666 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.000171 | uM | 11660.145 | 1.0000 | 1.0000 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.000853 | uM | 11660.145 | 0.9676 | 0.9293 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7931.017 | 0.9087 | 0.8629 | 1.3488 | |
| ZR-75-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 0.00427 | uM | 11660.145 | 1.0114 | 1.0248 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7931.017 | 0.9421 | 0.9135 | 1.3488 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7931.017 | 1.0332 | 1.0490 | 1.3488 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.316 | uM | 7552.095 | 0.8419 | 0.7130 | 1.1106 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 1.38 | uM | 7931.017 | 0.2740 | -0.2341 | 1.3488 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 6.9 | uM | 7931.017 | 0.4392 | 0.0866 | 1.3488 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 34.5 | uM | 7931.017 | 0.2743 | -0.2334 | 1.3488 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7932.017 | 0.9497 | 0.9059 | 1.0712 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.011 | uM | 7932.017 | 1.0164 | 1.0305 | 1.0712 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.276 | uM | 7932.017 | 0.5483 | 0.1413 | 1.0712 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 1.38 | uM | 7932.017 | 0.1980 | -0.5590 | 1.0712 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.000505 | uM | 7552.095 | 0.9283 | 0.8704 | 1.1106 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.0126 | uM | 7552.095 | 1.0020 | 1.0035 | 1.1106 | |
| ZR-75-1 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 11660.146 | 0.9165 | 0.8278 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 11660.146 | 0.6544 | 0.2909 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.000101 | uM | 7552.095 | 0.9771 | 0.9587 | 1.1106 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.0631 | uM | 7552.095 | 0.9728 | 0.9510 | 1.1106 | |
| ZR-75-1 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 12003.155 | 0.9802 | 0.9647 | 1.1249 |