LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 8 of 15: Cell count and normalized growth rate inhibition values within biological replicate 1. - Dataset (ID:20245)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Replicate | Assay Well | Timepoint | Timepoint Unit | Total Cell Count Before Treatment | Total Cell Count After Treatment | Total Control Cell Count | Relative Cell Count | Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | Afatinib | 0.04 | uM | LJP6 | 2 | G24 | 72 | hr | 513 | 293 | 10386 | 0.0282 | -0.1213 |
| MCF 10A | HG-6-64-01 | 10 | uM | LJP6 | 3 | M01 | 72 | hr | 513 | 293 | 10494 | 0.0279 | -0.1209 |
| MCF 10A | Dasatinib | 10 | uM | LJP5 | 1 | D01 | 72 | hr | 513 | 294 | 10254 | 0.0287 | -0.1211 |
| MCF 10A | CGP60474 | 10 | uM | LJP6 | 2 | G01 | 72 | hr | 513 | 298 | 10386 | 0.0287 | -0.1178 |
| MCF 10A | Withaferin A | 10 | uM | LJP6 | 2 | G13 | 72 | hr | 513 | 301 | 10386 | 0.0290 | -0.1158 |
| MCF 10A | Dasatinib | 3.33 | uM | LJP5 | 1 | D02 | 72 | hr | 513 | 303 | 10254 | 0.0295 | -0.1149 |
| MDA-MB-231 | Mitoxantrone | 10 | uM | LJP6 | 2 | C19 | 72 | hr | 868 | 305 | 3652 | 0.0835 | -0.3963 |
| MCF 10A | Buparlisib | 10 | uM | LJP5 | 2 | H01 | 72 | hr | 513 | 307 | 10349 | 0.0297 | -0.1119 |
| MDA-MB-231 | LDN-193189 | 10 | uM | LJP5 | 1 | G01 | 72 | hr | 868 | 309 | 3286 | 0.0940 | -0.4160 |
| MDA-MB-231 | Mitoxantrone | 10 | uM | LJP5 | 1 | C19 | 72 | hr | 868 | 309 | 3286 | 0.0940 | -0.4160 |
| MCF 10A | GSK1059615 | 10 | uM | LJP5 | 2 | E01 | 72 | hr | 513 | 312 | 10349 | 0.0301 | -0.1086 |
| MDA-MB-231 | Mitoxantrone | 10 | uM | LJP5 | 3 | C19 | 72 | hr | 868 | 312 | 3440 | 0.0907 | -0.4026 |
| MCF 10A | Dasatinib | 10 | uM | LJP5 | 2 | D01 | 72 | hr | 513 | 313 | 10349 | 0.0302 | -0.1079 |
| Hs 578T | Withaferin A | 10 | uM | LJP6 | 1 | G13 | 72 | hr | 929 | 315 | 3185 | 0.0989 | -0.4559 |
| MCF 10A | Geldanamycin | 10 | uM | LJP5 | 1 | O01 | 72 | hr | 513 | 315 | 10254 | 0.0307 | -0.1069 |
| MCF 10A | Buparlisib | 3.33 | uM | LJP5 | 1 | H02 | 72 | hr | 513 | 318 | 10254 | 0.0310 | -0.1049 |
| MCF7 | AZD 5438 | 10 | uM | LJP6 | 2 | J01 | 72 | hr | 1235 | 319 | 4070 | 0.0784 | -0.5448 |
| MCF 10A | Dasatinib | 3.33 | uM | LJP6 | 1 | I02 | 72 | hr | 513 | 320 | 10537 | 0.0304 | -0.1028 |
| MCF 10A | Dasatinib | 3.33 | uM | LJP5 | 2 | D02 | 72 | hr | 513 | 324 | 10349 | 0.0313 | -0.1008 |
| MCF 10A | QL-X-138 | 10 | uM | LJP6 | 1 | F19 | 72 | hr | 513 | 326 | 10537 | 0.0309 | -0.0989 |
| MCF7 | Alvocidib | 10 | uM | LJP6 | 1 | A13 | 72 | hr | 1235 | 329 | 3974 | 0.0828 | -0.5438 |
| MCF 10A | Geldanamycin | 3.33 | uM | LJP5 | 2 | O02 | 72 | hr | 513 | 329 | 10349 | 0.0318 | -0.0976 |
| MCF 10A | CGP60474 | 3.33 | uM | LJP6 | 1 | G02 | 72 | hr | 513 | 330 | 10537 | 0.0313 | -0.0964 |
| MCF7 | Mitoxantrone | 10 | uM | LJP5 | 3 | C19 | 72 | hr | 1235 | 332 | 4326 | 0.0767 | -0.5165 |
| MDA-MB-231 | LDN-193189 | 10 | uM | LJP5 | 2 | G01 | 72 | hr | 868 | 332 | 3505 | 0.0947 | -0.3796 |