LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 6 of 15: Mean cell count and mean growth rate across biological replicate 3. - Dataset (ID:20242)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 1235 | 259 | 4513 | 0.0575 | -0.2979 |
| MCF 10A | AZD 5438 | 3.33 | uM | LJP6 | 72 | hr | 962 | 260 | 10605 | 0.0246 | -0.0727 |
| MCF 10A | CGP60474 | 0.37 | uM | LJP5 | 72 | hr | 962 | 263 | 10605 | 0.0249 | -0.0724 |
| Hs 578T | AZD7762 | 3.33 | uM | LJP6 | 72 | hr | 658 | 272 | 3846 | 0.0707 | -0.1211 |
| MCF 10A | SNS-032 | 3.33 | uM | LJP6 | 72 | hr | 962 | 273 | 10605 | 0.0258 | -0.0714 |
| Hs 578T | Mitoxantrone | 1.11 | uM | LJP5 | 72 | hr | 658 | 276 | 3846 | 0.0718 | -0.1199 |
| MCF 10A | CGP60474 | 0.37 | uM | LJP6 | 72 | hr | 962 | 277 | 10605 | 0.0262 | -0.0710 |
| MCF 10A | CGP60474 | 10.0 | uM | LJP6 | 72 | hr | 962 | 279 | 10605 | 0.0263 | -0.0708 |
| Hs 578T | JW-7-24-1 | 10.0 | uM | LJP6 | 72 | hr | 658 | 280 | 3846 | 0.0730 | -0.1184 |
| MDA-MB-231 | SB590885 | 10.0 | uM | LJP5 | 72 | hr | 1235 | 280 | 4513 | 0.0621 | -0.2916 |
| MDA-MB-231 | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 283 | 4513 | 0.0628 | -0.2905 |
| Hs 578T | Mitoxantrone | 1.11 | uM | LJP6 | 72 | hr | 658 | 287 | 3846 | 0.0746 | -0.1164 |
| MCF 10A | CGP60474 | 3.33 | uM | LJP5 | 72 | hr | 962 | 292 | 10605 | 0.0275 | -0.0695 |
| MDA-MB-231 | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 292 | 4513 | 0.0647 | -0.2880 |
| MCF 10A | SNS-032 | 1.11 | uM | LJP6 | 72 | hr | 962 | 294 | 10605 | 0.0278 | -0.0692 |
| Hs 578T | A443654 | 3.33 | uM | LJP6 | 72 | hr | 658 | 294 | 3846 | 0.0764 | -0.1142 |
| Hs 578T | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 658 | 304 | 3846 | 0.0792 | -0.1109 |
| Hs 578T | A443654 | 1.11 | uM | LJP6 | 72 | hr | 658 | 308 | 3846 | 0.0802 | -0.1097 |
| MCF 10A | A443654 | 3.33 | uM | LJP6 | 72 | hr | 962 | 316 | 10605 | 0.0298 | -0.0670 |
| Hs 578T | BMS345541 | 10.0 | uM | LJP6 | 72 | hr | 658 | 317 | 3846 | 0.0825 | -0.1069 |
| MCF 10A | AT-7519 | 1.11 | uM | LJP6 | 72 | hr | 962 | 319 | 10605 | 0.0301 | -0.0667 |
| MCF 10A | Alvocidib | 0.12 | uM | LJP6 | 72 | hr | 962 | 320 | 10605 | 0.0302 | -0.0666 |
| MCF 10A | SNS-032 | 10.0 | uM | LJP6 | 72 | hr | 962 | 324 | 10605 | 0.0306 | -0.0661 |
| MDA-MB-231 | AT-7519 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 324 | 4513 | 0.0719 | -0.2780 |
| MCF 10A | CGP60474 | 10.0 | uM | LJP5 | 72 | hr | 962 | 326 | 10605 | 0.0307 | -0.0660 |