LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 6 of 15: Mean cell count and mean growth rate across biological replicate 3. - Dataset (ID:20242)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 962 | 194 | 10605 | 0.0183 | -0.0797 |
| MCF 10A | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 962 | 195 | 10605 | 0.0184 | -0.0795 |
| MCF 10A | Alvocidib | 0.37 | uM | LJP6 | 72 | hr | 962 | 200 | 10605 | 0.0189 | -0.0790 |
| BT-20 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1097 | 201 | 3769 | 0.0535 | -0.3351 |
| Hs 578T | AZD7762 | 10.0 | uM | LJP6 | 72 | hr | 658 | 203 | 3846 | 0.0530 | -0.1426 |
| MCF 10A | Alvocidib | 3.33 | uM | LJP6 | 72 | hr | 962 | 204 | 10605 | 0.0192 | -0.0786 |
| MDA-MB-231 | Mitoxantrone | 3.33 | uM | LJP6 | 72 | hr | 1235 | 205 | 4513 | 0.0455 | -0.3144 |
| MCF 10A | Canertinib | 10.0 | uM | LJP6 | 72 | hr | 962 | 208 | 10605 | 0.0196 | -0.0782 |
| Hs 578T | NVP-TAE684 | 10.0 | uM | LJP6 | 72 | hr | 658 | 210 | 3846 | 0.0548 | -0.1404 |
| BT-20 | LDN-193189 | 10.0 | uM | LJP5 | 72 | hr | 1097 | 211 | 3769 | 0.0562 | -0.3314 |
| MCF 10A | WZ3105 | 3.33 | uM | LJP5 | 72 | hr | 962 | 211 | 10605 | 0.0199 | -0.0779 |
| Hs 578T | LDN-193189 | 10.0 | uM | LJP5 | 72 | hr | 658 | 212 | 3846 | 0.0551 | -0.1400 |
| MCF 10A | Alvocidib | 1.11 | uM | LJP6 | 72 | hr | 962 | 212 | 10605 | 0.0200 | -0.0778 |
| Hs 578T | GSK1059615 | 10.0 | uM | LJP5 | 72 | hr | 658 | 223 | 3846 | 0.0581 | -0.1364 |
| MCF7 | JNK-9L | 10.0 | uM | LJP6 | 72 | hr | 1209 | 233 | 4093 | 0.0570 | -0.3386 |
| MDA-MB-231 | HG-6-64-01 | 10.0 | uM | LJP6 | 72 | hr | 1235 | 234 | 4513 | 0.0518 | -0.3057 |
| Hs 578T | Celastrol | 10.0 | uM | LJP6 | 72 | hr | 658 | 235 | 3846 | 0.0612 | -0.1326 |
| MCF 10A | CGP60474 | 1.11 | uM | LJP6 | 72 | hr | 962 | 236 | 10605 | 0.0223 | -0.0752 |
| MCF 10A | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 962 | 238 | 10605 | 0.0224 | -0.0751 |
| MCF 10A | CGP60474 | 1.11 | uM | LJP5 | 72 | hr | 962 | 245 | 10605 | 0.0231 | -0.0743 |
| MCF 10A | Alvocidib | 10.0 | uM | LJP6 | 72 | hr | 962 | 252 | 10605 | 0.0238 | -0.0736 |
| MCF 10A | CGP60474 | 0.12 | uM | LJP6 | 72 | hr | 962 | 253 | 10605 | 0.0239 | -0.0735 |
| MCF 10A | WZ3105 | 1.11 | uM | LJP5 | 72 | hr | 962 | 254 | 10605 | 0.0240 | -0.0734 |
| Hs 578T | A443654 | 10.0 | uM | LJP6 | 72 | hr | 658 | 258 | 3846 | 0.0671 | -0.1255 |
| MDA-MB-231 | Celastrol | 10.0 | uM | LJP6 | 72 | hr | 1235 | 259 | 4513 | 0.0575 | -0.2980 |