LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 6 of 15: Mean cell count and mean growth rate across biological replicate 3. - Dataset (ID:20242)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Torin2 | 0.37 | uM | LJP5 | 72 | hr | 1209 | 997 | 4093 | 0.2438 | -0.0735 |
| Hs 578T | Alvocidib | 1.11 | uM | LJP6 | 72 | hr | 658 | 424 | 3846 | 0.1102 | -0.0735 |
| MCF 10A | CGP60474 | 0.12 | uM | LJP6 | 72 | hr | 962 | 253 | 10605 | 0.0239 | -0.0735 |
| MCF 10A | WZ3105 | 1.11 | uM | LJP5 | 72 | hr | 962 | 254 | 10605 | 0.0240 | -0.0734 |
| Hs 578T | Geldanamycin | 10.0 | uM | LJP6 | 72 | hr | 658 | 425 | 3846 | 0.1105 | -0.0731 |
| MDA-MB-231 | QL-XII-47 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 997 | 4513 | 0.2209 | -0.0729 |
| MCF 10A | AZD 5438 | 3.33 | uM | LJP6 | 72 | hr | 962 | 260 | 10605 | 0.0246 | -0.0727 |
| MCF7 | Torin1 | 10.0 | uM | LJP6 | 72 | hr | 1209 | 1000 | 4093 | 0.2444 | -0.0726 |
| MCF 10A | CGP60474 | 0.37 | uM | LJP5 | 72 | hr | 962 | 263 | 10605 | 0.0249 | -0.0724 |
| MDA-MB-231 | BI-2536 | 0.04 | uM | LJP6 | 72 | hr | 1235 | 999 | 4513 | 0.2214 | -0.0722 |
| MCF7 | GDC-0980 | 0.12 | uM | LJP5 | 72 | hr | 1209 | 1002 | 4093 | 0.2450 | -0.0718 |
| SK-BR-3 | PF562271 | 10.0 | uM | LJP6 | 72 | hr | 1401 | 1199 | 4223 | 0.2839 | -0.0718 |
| MCF 10A | SNS-032 | 3.33 | uM | LJP6 | 72 | hr | 962 | 273 | 10605 | 0.0258 | -0.0714 |
| BT-20 | AZD8055 | 3.33 | uM | LJP6 | 72 | hr | 1097 | 906 | 3769 | 0.2405 | -0.0713 |
| MCF7 | GDC-0980 | 3.33 | uM | LJP5 | 72 | hr | 1209 | 1004 | 4093 | 0.2453 | -0.0713 |
| Hs 578T | WZ3105 | 0.12 | uM | LJP5 | 72 | hr | 658 | 431 | 3846 | 0.1122 | -0.0711 |
| Hs 578T | Foretinib | 10.0 | uM | LJP5 | 72 | hr | 658 | 431 | 3846 | 0.1122 | -0.0711 |
| MDA-MB-231 | Withaferin A | 1.11 | uM | LJP5 | 72 | hr | 1235 | 1003 | 4513 | 0.2222 | -0.0711 |
| MCF 10A | CGP60474 | 0.37 | uM | LJP6 | 72 | hr | 962 | 277 | 10605 | 0.0262 | -0.0710 |
| MDA-MB-231 | Radicicol | 1.11 | uM | LJP5 | 72 | hr | 1235 | 1004 | 4513 | 0.2224 | -0.0708 |
| MCF 10A | CGP60474 | 10.0 | uM | LJP6 | 72 | hr | 962 | 279 | 10605 | 0.0263 | -0.0708 |
| MDA-MB-231 | Nilotinib | 10.0 | uM | LJP5 | 72 | hr | 1235 | 1004 | 4513 | 0.2226 | -0.0706 |
| SK-BR-3 | Mitoxantrone | 1.11 | uM | LJP5 | 72 | hr | 1401 | 1203 | 4223 | 0.2849 | -0.0702 |
| MCF7 | PI103 | 1.11 | uM | LJP6 | 72 | hr | 1209 | 1007 | 4093 | 0.2462 | -0.0700 |
| Hs 578T | CGP60474 | 1.11 | uM | LJP5 | 72 | hr | 658 | 435 | 3846 | 0.1132 | -0.0699 |