LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 6 of 15: Mean cell count and mean growth rate across biological replicate 3. - Dataset (ID:20242)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | PHA-793887 | 3.33 | uM | LJP6 | 72 | hr | 1209 | 745 | 4093 | 0.1821 | -0.1610 |
| SK-BR-3 | Alvocidib | 1.11 | uM | LJP6 | 72 | hr | 1401 | 948 | 4223 | 0.2245 | -0.1607 |
| Hs 578T | Mitoxantrone | 3.33 | uM | LJP6 | 72 | hr | 658 | 147 | 3846 | 0.0384 | -0.1601 |
| BT-20 | Torin1 | 10.0 | uM | LJP6 | 72 | hr | 1097 | 669 | 3769 | 0.1777 | -0.1600 |
| SK-BR-3 | AT-7519 | 1.11 | uM | LJP6 | 72 | hr | 1401 | 953 | 4223 | 0.2257 | -0.1589 |
| Hs 578T | Mitoxantrone | 3.33 | uM | LJP5 | 72 | hr | 658 | 154 | 3846 | 0.0401 | -0.1581 |
| MDA-MB-231 | QL-XII-47 | 10.0 | uM | LJP6 | 72 | hr | 1235 | 717 | 4513 | 0.1590 | -0.1581 |
| BT-20 | QL-X-138 | 10.0 | uM | LJP6 | 72 | hr | 1097 | 675 | 3769 | 0.1791 | -0.1580 |
| SK-BR-3 | GSK1059615 | 3.33 | uM | LJP6 | 72 | hr | 1401 | 956 | 4223 | 0.2265 | -0.1577 |
| SK-BR-3 | WZ3105 | 3.33 | uM | LJP5 | 72 | hr | 1401 | 957 | 4223 | 0.2267 | -0.1574 |
| SK-BR-3 | Alvocidib | 0.37 | uM | LJP6 | 72 | hr | 1401 | 959 | 4223 | 0.2272 | -0.1566 |
| MDA-MB-231 | Omipalisib | 10.0 | uM | LJP6 | 72 | hr | 1235 | 723 | 4513 | 0.1602 | -0.1565 |
| MDA-MB-231 | A443654 | 0.37 | uM | LJP6 | 72 | hr | 1235 | 726 | 4513 | 0.1609 | -0.1556 |
| SK-BR-3 | Alvocidib | 0.12 | uM | LJP6 | 72 | hr | 1401 | 964 | 4223 | 0.2284 | -0.1548 |
| MDA-MB-231 | AZD7762 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 729 | 4513 | 0.1615 | -0.1547 |
| MCF7 | AZD 5438 | 1.11 | uM | LJP6 | 72 | hr | 1209 | 768 | 4093 | 0.1877 | -0.1530 |
| SK-BR-3 | Alvocidib | 10.0 | uM | LJP6 | 72 | hr | 1401 | 970 | 4223 | 0.2299 | -0.1527 |
| MDA-MB-231 | PD0325901 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 735 | 4513 | 0.1630 | -0.1526 |
| BT-20 | SNS-032 | 0.37 | uM | LJP6 | 72 | hr | 1097 | 691 | 3769 | 0.1833 | -0.1520 |
| BT-20 | Mitoxantrone | 3.33 | uM | LJP5 | 72 | hr | 1097 | 691 | 3769 | 0.1834 | -0.1519 |
| MCF7 | WZ-4-145 | 10.0 | uM | LJP6 | 72 | hr | 1209 | 772 | 4093 | 0.1887 | -0.1516 |
| MDA-MB-231 | Geldanamycin | 3.33 | uM | LJP5 | 72 | hr | 1235 | 743 | 4513 | 0.1647 | -0.1503 |
| SK-BR-3 | Buparlisib | 10.0 | uM | LJP5 | 72 | hr | 1401 | 978 | 4223 | 0.2317 | -0.1500 |
| MCF7 | BI-2536 | 10.0 | uM | LJP6 | 72 | hr | 1209 | 777 | 4093 | 0.1900 | -0.1498 |
| Hs 578T | LDN-193189 | 3.33 | uM | LJP5 | 72 | hr | 658 | 183 | 3846 | 0.0476 | -0.1491 |