LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 6 of 15: Mean cell count and mean growth rate across biological replicate 3. - Dataset (ID:20242)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Mitoxantrone | 0.12 | uM | LJP6 | 72 | hr | 658 | 602 | 3846 | 0.1567 | -0.0174 |
| MCF7 | CGP60474 | 3.33 | uM | LJP5 | 72 | hr | 1209 | 642 | 4093 | 0.1569 | -0.1967 |
| MCF7 | Y39983 | 10.0 | uM | LJP6 | 72 | hr | 1209 | 642 | 4093 | 0.1569 | -0.1967 |
| MDA-MB-231 | Foretinib | 10.0 | uM | LJP5 | 72 | hr | 1235 | 708 | 4513 | 0.1569 | -0.1610 |
| MCF7 | PF431396 | 10.0 | uM | LJP5 | 72 | hr | 1209 | 642 | 4093 | 0.1570 | -0.1966 |
| MCF7 | Alvocidib | 0.37 | uM | LJP6 | 72 | hr | 1209 | 643 | 4093 | 0.1572 | -0.1964 |
| BT-20 | CGP60474 | 3.33 | uM | LJP5 | 72 | hr | 1097 | 593 | 3769 | 0.1574 | -0.1886 |
| Hs 578T | XMD16-144 | 3.33 | uM | LJP5 | 72 | hr | 658 | 605 | 3846 | 0.1574 | -0.0166 |
| Hs 578T | Mitoxantrone | 0.04 | uM | LJP6 | 72 | hr | 658 | 605 | 3846 | 0.1575 | -0.0165 |
| Hs 578T | TWS119 | 10.0 | uM | LJP5 | 72 | hr | 658 | 606 | 3846 | 0.1576 | -0.0164 |
| MCF 10A | HG-5-113-01 | 3.33 | uM | LJP5 | 72 | hr | 962 | 1672 | 10605 | 0.1577 | 0.0736 |
| BT-20 | Radicicol | 10.0 | uM | LJP6 | 72 | hr | 1097 | 595 | 3769 | 0.1580 | -0.1877 |
| MCF 10A | Dovitinib | 1.11 | uM | LJP5 | 72 | hr | 962 | 1676 | 10605 | 0.1581 | 0.0741 |
| MCF7 | PHA-793887 | 10.0 | uM | LJP6 | 72 | hr | 1209 | 647 | 4093 | 0.1581 | -0.1951 |
| Hs 578T | Dasatinib | 10.0 | uM | LJP5 | 72 | hr | 658 | 608 | 3846 | 0.1582 | -0.0156 |
| BT-20 | GSK1059615 | 1.11 | uM | LJP5 | 72 | hr | 1097 | 596 | 3769 | 0.1583 | -0.1873 |
| Hs 578T | Radicicol | 10.0 | uM | LJP6 | 72 | hr | 658 | 609 | 3846 | 0.1585 | -0.0152 |
| MDA-MB-231 | QL-XII-47 | 10.0 | uM | LJP6 | 72 | hr | 1235 | 717 | 4513 | 0.1590 | -0.1581 |
| MCF 10A | AZD8330 | 0.12 | uM | LJP5 | 72 | hr | 962 | 1687 | 10605 | 0.1591 | 0.0752 |
| MCF7 | Alvocidib | 1.11 | uM | LJP6 | 72 | hr | 1209 | 652 | 4093 | 0.1593 | -0.1934 |
| MCF7 | AT-7519 | 0.12 | uM | LJP6 | 72 | hr | 1209 | 653 | 4093 | 0.1595 | -0.1930 |
| MCF 10A | Selumetinib | 10.0 | uM | LJP6 | 72 | hr | 962 | 1692 | 10605 | 0.1596 | 0.0758 |
| MDA-MB-231 | Omipalisib | 10.0 | uM | LJP6 | 72 | hr | 1235 | 723 | 4513 | 0.1602 | -0.1565 |
| Hs 578T | XMD11-50 | 10.0 | uM | LJP6 | 72 | hr | 658 | 616 | 3846 | 0.1603 | -0.0131 |
| BT-20 | Geldanamycin | 10.0 | uM | LJP6 | 72 | hr | 1097 | 604 | 3769 | 0.1604 | -0.1843 |