LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 6 of 15: Mean cell count and mean growth rate across biological replicate 3. - Dataset (ID:20242)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | AZD 5438 | 3.33 | uM | LJP6 | 72 | hr | 962 | 260 | 10605 | 0.0246 | -0.0727 |
| MCF 10A | CGP60474 | 0.37 | uM | LJP5 | 72 | hr | 962 | 263 | 10605 | 0.0249 | -0.0724 |
| SK-BR-3 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1401 | 109 | 4223 | 0.0258 | -0.4581 |
| MCF 10A | SNS-032 | 3.33 | uM | LJP6 | 72 | hr | 962 | 273 | 10605 | 0.0258 | -0.0714 |
| MCF 10A | CGP60474 | 0.37 | uM | LJP6 | 72 | hr | 962 | 277 | 10605 | 0.0262 | -0.0710 |
| MCF 10A | CGP60474 | 10.0 | uM | LJP6 | 72 | hr | 962 | 279 | 10605 | 0.0263 | -0.0708 |
| Hs 578T | AZD8055 | 10.0 | uM | LJP6 | 72 | hr | 658 | 103 | 3846 | 0.0270 | -0.1739 |
| MCF 10A | CGP60474 | 3.33 | uM | LJP5 | 72 | hr | 962 | 292 | 10605 | 0.0275 | -0.0695 |
| MCF 10A | SNS-032 | 1.11 | uM | LJP6 | 72 | hr | 962 | 294 | 10605 | 0.0278 | -0.0692 |
| MDA-MB-231 | PHA-665752 | 10.0 | uM | LJP5 | 72 | hr | 1235 | 131 | 4513 | 0.0291 | -0.3370 |
| MCF 10A | A443654 | 3.33 | uM | LJP6 | 72 | hr | 962 | 316 | 10605 | 0.0298 | -0.0670 |
| MCF 10A | AT-7519 | 1.11 | uM | LJP6 | 72 | hr | 962 | 319 | 10605 | 0.0301 | -0.0667 |
| MCF 10A | Alvocidib | 0.12 | uM | LJP6 | 72 | hr | 962 | 320 | 10605 | 0.0302 | -0.0666 |
| MCF 10A | SNS-032 | 10.0 | uM | LJP6 | 72 | hr | 962 | 324 | 10605 | 0.0306 | -0.0661 |
| MCF 10A | CGP60474 | 10.0 | uM | LJP5 | 72 | hr | 962 | 326 | 10605 | 0.0307 | -0.0660 |
| MCF 10A | AZD 5438 | 10.0 | uM | LJP6 | 72 | hr | 962 | 333 | 10605 | 0.0314 | -0.0652 |
| BT-20 | AZD8055 | 10.0 | uM | LJP6 | 72 | hr | 1097 | 119 | 3769 | 0.0317 | -0.3658 |
| Hs 578T | SB590885 | 10.0 | uM | LJP5 | 72 | hr | 658 | 125 | 3846 | 0.0327 | -0.1670 |
| MCF 10A | PHA-793887 | 10.0 | uM | LJP6 | 72 | hr | 962 | 359 | 10605 | 0.0339 | -0.0625 |
| MCF 10A | PF562271 | 10.0 | uM | LJP6 | 72 | hr | 962 | 369 | 10605 | 0.0348 | -0.0615 |
| MCF 10A | Celastrol | 3.33 | uM | LJP6 | 72 | hr | 962 | 374 | 10605 | 0.0353 | -0.0609 |
| MCF 10A | Mitoxantrone | 3.33 | uM | LJP5 | 72 | hr | 962 | 380 | 10605 | 0.0359 | -0.0603 |
| MCF 10A | Radicicol | 10.0 | uM | LJP6 | 72 | hr | 962 | 381 | 10605 | 0.0360 | -0.0602 |
| MCF 10A | CGP60474 | 0.12 | uM | LJP5 | 72 | hr | 962 | 387 | 10605 | 0.0365 | -0.0596 |
| MCF 10A | Geldanamycin | 10.0 | uM | LJP6 | 72 | hr | 962 | 393 | 10605 | 0.0371 | -0.0590 |