PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MZ7-mel | 24 | hr | p27 Kip1 | -6.63380 | 0.73834 |
| K2 | 48 | hr | p-HSP27(S82) | -6.59030 | -0.08416 |
| K2 | 48 | hr | Total c-Jun | -6.49180 | 0.01079 |
| K2 | 48 | hr | p-P38(T180/Y182) | -6.42700 | 1.07700 |
| C32 | 24 | hr | p27 Kip1 | -6.36380 | 0.34918 |
| K2 | 48 | hr | p-p90RSK(S380) | -6.28150 | 1.09300 |
| MMAC-SF | 24 | hr | p-AKT(S473) | -6.22540 | -0.68100 |
| RVH-421 | 24 | hr | Total c-Jun | -6.15220 | 0.71907 |
| K2 | 24 | hr | p27 Kip1 | -6.14120 | -0.28155 |
| MMAC-SF | 24 | hr | p-JNK(T183/Y185) | -6.10280 | 1.14500 |
| K2 | 48 | hr | p-JNK(T183/Y185) | -6.01540 | 0.83886 |
| MZ7-mel | 24 | hr | Bim | -6.01010 | -0.84793 |
| MZ7-mel | 24 | hr | cPARP | -6.00290 | 0.23558 |
| WM1552C | 24 | hr | p-S6(S235/236) | -5.86750 | -1.83620 |
| K2 | 24 | hr | p-AKT(S473) | -5.85670 | 1.20820 |
| K2 | 24 | hr | Bim | -5.83140 | -0.01586 |
| C32 | 24 | hr | Bim | -5.80310 | 0.97812 |
| SKMEL28 | 48 | hr | Bim | -5.79870 | -1.44570 |
| RVH-421 | 48 | hr | Total c-Jun | -5.78540 | -1.36930 |
| K2 | 24 | hr | cPARP | -5.59320 | 1.04550 |
| K2 | 24 | hr | p-NFKB(S536) | -5.30830 | 0.31391 |
| RVH-421 | 24 | hr | p27 Kip1 | -5.29960 | -1.22490 |
| K2 | 24 | hr | p-JNK(T183/Y185) | -5.15050 | 1.48320 |
| K2 | 24 | hr | p-p90RSK(S380) | -5.12670 | 1.29540 |
| K2 | 48 | hr | p-AMPK(T172) | -5.12430 | 0.70245 |