PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM1552C | 24 | hr | p-HSP27(S82) | 0.60546 | -0.75231 |
| WM1552C | 24 | hr | p-NFKB(S536) | 1.54790 | -0.19505 |
| WM1552C | 24 | hr | Bim | -2.77770 | -3.72120 |
| WM1552C | 24 | hr | cPARP | -0.54882 | -1.44190 |
| WM1552C | 24 | hr | p-Histone H3(S10) | 2.95860 | 0.96737 |
| WM1552C | 24 | hr | p27 Kip1 | 2.59490 | -0.24387 |
| WM1552C | 48 | hr | p-p90RSK(S380) | 5.86460 | 0.07177 |
| WM1552C | 48 | hr | p-p90RSK(T573) | 2.94700 | -0.93695 |
| WM1552C | 48 | hr | p-AKT(T308) | 2.06670 | -0.68977 |
| WM1552C | 48 | hr | p-AKT(S473) | -0.93725 | -2.61410 |
| WM1552C | 48 | hr | p-mTOR(S2448) | 4.74340 | -0.64410 |
| WM1552C | 48 | hr | p-p70S6K(T421/S424) | 4.77520 | -1.00400 |
| WM1552C | 48 | hr | p-p70S6K(T389) | 4.61770 | -1.23610 |
| WM1552C | 48 | hr | p-S6(S235/236) | -0.47190 | -1.54910 |
| WM1552C | 48 | hr | p-AMPK(T172) | 3.71970 | -1.00740 |
| WM1552C | 48 | hr | p-JNK(T183/Y185) | 4.65550 | -0.03754 |
| WM1552C | 48 | hr | Total c-Jun | 2.44630 | -1.50090 |
| WM1552C | 48 | hr | p-cJun(S63) | -1.23800 | -3.28480 |
| WM1552C | 48 | hr | p-P38(T180/Y182) | 4.65380 | -0.49583 |
| WM1552C | 48 | hr | p-HSP27(S82) | 3.20660 | -0.77687 |
| WM1552C | 48 | hr | p-NFKB(S536) | 5.73030 | 0.44840 |
| WM1552C | 48 | hr | Bim | 2.39580 | -2.69920 |
| WM1552C | 48 | hr | cPARP | 5.66920 | -0.07164 |
| WM1552C | 48 | hr | p-Histone H3(S10) | 7.22950 | 2.75000 |
| WM1552C | 48 | hr | p27 Kip1 | 3.14570 | -1.05530 |