PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| LOXIMVI | 10 | hr | Bim | 1.62650 | 0.28689 |
| MZ7-mel | 10 | hr | p-AMPK(T172) | -0.35369 | -0.45966 |
| K2 | 10 | hr | pERK(T202/Y204) | 9.61160 | 1.06950 |
| K2 | 10 | hr | p-p90RSK(S380) | 1.14340 | 0.02050 |
| MZ7-mel | 10 | hr | p-HSP27(S82) | 0.25789 | -0.12412 |
| MZ7-mel | 10 | hr | p-p90RSK(T573) | 0.05237 | -0.14992 |
| LOXIMVI | 10 | hr | p-JNK(T183/Y185) | 1.52130 | 0.17262 |
| MZ7-mel | 10 | hr | p-AKT(T308) | -0.02746 | -0.19614 |
| LOXIMVI | 10 | hr | Total c-Jun | 2.10780 | -0.47824 |
| C32 | 10 | hr | pMEK(S217/221) | 2.58930 | -1.40120 |
| MZ7-mel | 10 | hr | p-p90RSK(S380) | 0.92807 | -0.10742 |
| MZ7-mel | 10 | hr | p-AKT(S473) | 0.74008 | -0.43971 |
| LOXIMVI | 10 | hr | p-AKT(T308) | NaN | NaN |
| LOXIMVI | 10 | hr | p-cJun(S63) | 0.56429 | 0.43862 |
| MZ7-mel | 10 | hr | pMEK(S217/221) | 4.47360 | -1.33890 |
| COLO 858 | 10 | hr | p27 Kip1 | -0.44752 | -0.96292 |
| LOXIMVI | 10 | hr | p-AMPK(T172) | 1.25840 | -0.09220 |
| MZ7-mel | 10 | hr | pERK(T202/Y204) | 10.72900 | 0.27725 |
| MZ7-mel | 10 | hr | p-mTOR(S2448) | 0.26138 | -0.00725 |
| COLO 858 | 10 | hr | p-Histone H3(S10) | 0.72294 | -0.45642 |
| COLO 858 | 10 | hr | cPARP | 1.47780 | -0.42932 |
| COLO 858 | 10 | hr | Bim | -0.23085 | -1.16470 |
| COLO 858 | 10 | hr | p-NFKB(S536) | 2.47130 | -0.76557 |
| COLO 858 | 10 | hr | p-HSP27(S82) | 0.09046 | -0.22953 |
| COLO 858 | 10 | hr | p-P38(T180/Y182) | 2.62340 | 0.86053 |