PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| SKMEL28 | 24 | hr | p-p90RSK(S380) | 0.24067 | 0.43490 |
| SKMEL28 | 24 | hr | p-p90RSK(T573) | -0.80013 | 0.33565 |
| SKMEL28 | 24 | hr | p-AKT(T308) | NaN | NaN |
| SKMEL28 | 24 | hr | p-AKT(S473) | -0.39570 | -0.20520 |
| SKMEL28 | 24 | hr | p-mTOR(S2448) | 1.32310 | -0.01075 |
| SKMEL28 | 24 | hr | p-p70S6K(T421/S424) | 1.30530 | -0.03920 |
| SKMEL28 | 24 | hr | p-p70S6K(T389) | 1.26830 | 0.12473 |
| SKMEL28 | 24 | hr | p-S6(S235/236) | 5.56150 | -0.53446 |
| SKMEL28 | 24 | hr | p-AMPK(T172) | -1.14040 | 0.04959 |
| SKMEL28 | 24 | hr | p-JNK(T183/Y185) | -0.73842 | -0.11067 |
| SKMEL28 | 24 | hr | Total c-Jun | -0.13867 | -0.03384 |
| SKMEL28 | 24 | hr | p-cJun(S63) | -0.57728 | 0.12976 |
| SKMEL28 | 24 | hr | p-P38(T180/Y182) | -2.60370 | -0.31292 |
| SKMEL28 | 24 | hr | p-HSP27(S82) | -0.23762 | 0.14007 |
| SKMEL28 | 24 | hr | p-NFKB(S536) | 1.10070 | 0.19120 |
| SKMEL28 | 24 | hr | Bim | -2.36590 | -0.23922 |
| SKMEL28 | 24 | hr | cPARP | -1.27940 | -0.47872 |
| SKMEL28 | 24 | hr | p-Histone H3(S10) | 9.44490 | -0.13301 |
| SKMEL28 | 24 | hr | p27 Kip1 | -2.71340 | -0.44041 |
| SKMEL28 | 48 | hr | pMEK(S217/221) | 3.77550 | -3.05560 |
| SKMEL28 | 48 | hr | pERK(T202/Y204) | 7.67850 | 0.77446 |
| SKMEL28 | 48 | hr | p-p90RSK(S380) | 0.78665 | 1.07880 |
| SKMEL28 | 48 | hr | p-p90RSK(T573) | 0.96745 | 1.09550 |
| SKMEL28 | 48 | hr | p-AKT(T308) | NaN | NaN |
| SKMEL28 | 48 | hr | p-AKT(S473) | -0.18915 | -0.39227 |