PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MMAC-SF | 24 | hr | Bim | -4.87780 | -0.28308 |
| MMAC-SF | 24 | hr | cPARP | -3.04780 | -0.63563 |
| MMAC-SF | 24 | hr | p-Histone H3(S10) | 5.18890 | 1.32950 |
| MMAC-SF | 24 | hr | p27 Kip1 | -3.49340 | -0.71038 |
| MMAC-SF | 48 | hr | pMEK(S217/221) | 4.31200 | -2.24210 |
| MMAC-SF | 48 | hr | pERK(T202/Y204) | 8.74170 | 0.14485 |
| MMAC-SF | 48 | hr | p-p90RSK(S380) | 1.72350 | -0.25914 |
| MMAC-SF | 48 | hr | p-p90RSK(T573) | 2.79590 | -0.60188 |
| MMAC-SF | 48 | hr | p-AKT(T308) | NaN | NaN |
| MMAC-SF | 48 | hr | p-AKT(S473) | 0.47390 | -0.37208 |
| MMAC-SF | 48 | hr | p-mTOR(S2448) | 1.25680 | -0.11525 |
| MMAC-SF | 48 | hr | p-p70S6K(T421/S424) | 1.84290 | -0.19256 |
| MMAC-SF | 48 | hr | p-p70S6K(T389) | 1.54490 | 0.03748 |
| MMAC-SF | 48 | hr | p-S6(S235/236) | 9.39020 | 1.17650 |
| MMAC-SF | 48 | hr | p-AMPK(T172) | 2.05770 | -0.00732 |
| MMAC-SF | 48 | hr | p-JNK(T183/Y185) | 1.24350 | 0.03051 |
| MMAC-SF | 48 | hr | Total c-Jun | 2.48330 | -0.10738 |
| MMAC-SF | 48 | hr | p-cJun(S63) | 0.95263 | -0.30750 |
| MMAC-SF | 48 | hr | p-P38(T180/Y182) | 0.90719 | 0.06669 |
| MMAC-SF | 48 | hr | p-HSP27(S82) | 0.23333 | -0.22594 |
| MMAC-SF | 48 | hr | p-NFKB(S536) | 1.79410 | -0.21413 |
| MMAC-SF | 48 | hr | Bim | 0.07707 | -0.33320 |
| MMAC-SF | 48 | hr | cPARP | -0.26600 | -0.44925 |
| MMAC-SF | 48 | hr | p-Histone H3(S10) | 6.33040 | 0.53713 |
| MMAC-SF | 48 | hr | p27 Kip1 | -0.09380 | -0.39766 |