Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JNK-IN-8 | WM1552C | 0.0205 | uM | 24 | hr | | Ki-67 | 1616.70 | p-Rb(S807/S811) | 107.97 | p-cJun(S73) | 148.06 | 1 | WM1552C-signal3 | D8 | |
| Vemurafenib | WM1552C | 0.3200 | uM | 24 | hr | | Ki-67 | 1222.80 | p-Rb(S807/S811) | 74.23 | p-cJun(S73) | 158.69 | 2 | WM1552C-signal3 | C5 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0512 | uM | 24 | hr | | Ki-67 | 1383.60 | p-Rb(S807/S811) | 94.09 | p-cJun(S73) | 155.54 | 2 | WM1552C-signal3 | G7 |
| Vemurafenib | WM1552C | 0.1280 | uM | 24 | hr | | Ki-67 | 1348.40 | p-Rb(S807/S811) | 86.19 | p-cJun(S73) | 162.31 | 2 | WM1552C-signal3 | C6 | |
| Vemurafenib | WM1552C | 0.0033 | uM | 24 | hr | | Ki-67 | 1609.30 | p-Rb(S807/S811) | 102.99 | p-cJun(S73) | 143.15 | 2 | WM1552C-signal3 | C10 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0000 | uM | 24 | hr | | Ki-67 | 1730.30 | p-Rb(S807/S811) | 108.00 | p-cJun(S73) | 145.49 | 2 | WM1552C-signal3 | G11 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0205 | uM | 24 | hr | | Ki-67 | 1521.80 | p-Rb(S807/S811) | 102.62 | p-cJun(S73) | 152.55 | 1 | WM1552C-signal3 | F8 |
| JNK-IN-8 | WM1552C | 0.0082 | uM | 24 | hr | | Ki-67 | 1563.50 | p-Rb(S807/S811) | 102.65 | p-cJun(S73) | 151.31 | 1 | WM1552C-signal3 | D9 | |
| JNK-IN-8 | WM1552C | 0.3200 | uM | 24 | hr | | Ki-67 | 1603.10 | p-Rb(S807/S811) | 108.59 | p-cJun(S73) | 104.20 | 2 | WM1552C-signal3 | E5 | |
| Vemurafenib | WM1552C | 2.0000 | uM | 24 | hr | | Ki-67 | 885.89 | p-Rb(S807/S811) | 44.19 | p-cJun(S73) | 99.31 | 2 | WM1552C-signal3 | C3 | |
| JNK-IN-8 | WM1552C | 0.0000 | uM | 24 | hr | | Ki-67 | 1603.40 | p-Rb(S807/S811) | 107.85 | p-cJun(S73) | 142.51 | 1 | WM1552C-signal3 | D11 | |
| JNK-IN-8 | WM1552C | 0.3200 | uM | 24 | hr | | Ki-67 | 1583.90 | p-Rb(S807/S811) | 110.94 | p-cJun(S73) | 105.82 | 1 | WM1552C-signal3 | D5 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 2.0000 | uM | 24 | hr | | Ki-67 | 1000.20 | p-Rb(S807/S811) | 47.24 | p-cJun(S73) | 12.90 | 1 | WM1552C-signal3 | F3 |
| Vemurafenib | WM1552C | 0.0512 | uM | 24 | hr | | Ki-67 | 1417.80 | p-Rb(S807/S811) | 90.84 | p-cJun(S73) | 153.01 | 2 | WM1552C-signal3 | C7 | |
| JNK-IN-8 | WM1552C | 0.0033 | uM | 24 | hr | | Ki-67 | 1617.60 | p-Rb(S807/S811) | 109.79 | p-cJun(S73) | 144.59 | 1 | WM1552C-signal3 | D10 | |
| JNK-IN-8 | WM1552C | 0.0033 | uM | 24 | hr | | Ki-67 | 1634.60 | p-Rb(S807/S811) | 105.63 | p-cJun(S73) | 145.10 | 2 | WM1552C-signal3 | E10 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0000 | uM | 24 | hr | | Ki-67 | 1640.70 | p-Rb(S807/S811) | 107.50 | p-cJun(S73) | 145.58 | 1 | WM1552C-signal3 | F11 |
| JNK-IN-8 | WM1552C | 2.0000 | uM | 24 | hr | | Ki-67 | 1543.30 | p-Rb(S807/S811) | 112.25 | p-cJun(S73) | 28.35 | 1 | WM1552C-signal3 | D3 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | p-Rb(S807/S811) | p-S6(S235/S236 | 1 | WM115-signal2 | F8 | |||
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | p-Rb(S807/S811) | p-S6(S235/S236 | 1 | WM115-signal2 | F9 |