Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JNK-IN-8 | LOXIMVI | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 260.69 | p-Rb(S807/S811) | 241.93 | p-S6(S235/S236 | 501.67 | 2 | LOXIMVI-signal2 | E5 | |
| JNK-IN-8 | LOXIMVI | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 282.86 | p-Rb(S807/S811) | 236.08 | p-S6(S235/S236 | 480.10 | 2 | LOXIMVI-signal2 | E6 | |
| JNK-IN-8 | LOXIMVI | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 283.60 | p-Rb(S807/S811) | 227.06 | p-S6(S235/S236 | 453.19 | 2 | LOXIMVI-signal2 | E7 | |
| JNK-IN-8 | LOXIMVI | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 281.63 | p-Rb(S807/S811) | 231.63 | p-S6(S235/S236 | 455.97 | 2 | LOXIMVI-signal2 | E8 | |
| JNK-IN-8 | LOXIMVI | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 254.16 | p-Rb(S807/S811) | 231.99 | p-S6(S235/S236 | 458.18 | 2 | LOXIMVI-signal2 | E9 | |
| Vemurafenib | LOXIMVI | 0.0033 | uM | 24 | hr | | Ki-67 | 2929.90 | p-Rb(S807/S811) | 202.41 | p-cJun(S73) | 113.58 | 1 | LOXIMVI-signal3 | B10 | |
| Vemurafenib | LOXIMVI | 0.0000 | uM | 24 | hr | | Ki-67 | 3070.70 | p-Rb(S807/S811) | 206.62 | p-cJun(S73) | 122.85 | 1 | LOXIMVI-signal3 | B11 | |
| Vemurafenib | LOXIMVI | 5.0000 | uM | 24 | hr | | Ki-67 | 2047.60 | p-Rb(S807/S811) | 78.14 | p-cJun(S73) | 80.02 | 1 | LOXIMVI-signal3 | B2 | |
| Vemurafenib | LOXIMVI | 2.0000 | uM | 24 | hr | | Ki-67 | 2059.50 | p-Rb(S807/S811) | 90.66 | p-cJun(S73) | 86.47 | 1 | LOXIMVI-signal3 | B3 | |
| Vemurafenib | LOXIMVI | 0.8000 | uM | 24 | hr | | Ki-67 | 2357.40 | p-Rb(S807/S811) | 128.12 | p-cJun(S73) | 82.54 | 1 | LOXIMVI-signal3 | B4 | |
| Vemurafenib | LOXIMVI | 0.3200 | uM | 24 | hr | | Ki-67 | 2470.00 | p-Rb(S807/S811) | 138.22 | p-cJun(S73) | 75.91 | 1 | LOXIMVI-signal3 | B5 | |
| Vemurafenib | LOXIMVI | 0.1280 | uM | 24 | hr | | Ki-67 | 2653.30 | p-Rb(S807/S811) | 167.23 | p-cJun(S73) | 86.38 | 1 | LOXIMVI-signal3 | B6 | |
| Vemurafenib | LOXIMVI | 0.0512 | uM | 24 | hr | | Ki-67 | 2730.30 | p-Rb(S807/S811) | 177.84 | p-cJun(S73) | 95.29 | 1 | LOXIMVI-signal3 | B7 | |
| Vemurafenib | LOXIMVI | 0.0205 | uM | 24 | hr | | Ki-67 | 2785.20 | p-Rb(S807/S811) | 185.62 | p-cJun(S73) | 96.25 | 1 | LOXIMVI-signal3 | B8 | |
| Vemurafenib | LOXIMVI | 0.0082 | uM | 24 | hr | | Ki-67 | 2905.80 | p-Rb(S807/S811) | 198.95 | p-cJun(S73) | 109.56 | 1 | LOXIMVI-signal3 | B9 | |
| Vemurafenib | LOXIMVI | 0.0033 | uM | 24 | hr | | Ki-67 | 2960.60 | p-Rb(S807/S811) | 197.88 | p-cJun(S73) | 114.95 | 2 | LOXIMVI-signal3 | C10 | |
| Vemurafenib | LOXIMVI | 0.0000 | uM | 24 | hr | | Ki-67 | 3001.50 | p-Rb(S807/S811) | 195.98 | p-cJun(S73) | 118.37 | 2 | LOXIMVI-signal3 | C11 | |
| Vemurafenib | LOXIMVI | 5.0000 | uM | 24 | hr | | Ki-67 | 1979.00 | p-Rb(S807/S811) | 73.51 | p-cJun(S73) | 77.14 | 2 | LOXIMVI-signal3 | C2 | |
| Vemurafenib | LOXIMVI | 2.0000 | uM | 24 | hr | | Ki-67 | 2153.30 | p-Rb(S807/S811) | 92.72 | p-cJun(S73) | 84.91 | 2 | LOXIMVI-signal3 | C3 | |
| Vemurafenib | LOXIMVI | 0.8000 | uM | 24 | hr | | Ki-67 | 2448.30 | p-Rb(S807/S811) | 126.79 | p-cJun(S73) | 81.56 | 2 | LOXIMVI-signal3 | C4 | |
| Vemurafenib | LOXIMVI | 0.3200 | uM | 24 | hr | | Ki-67 | 2387.10 | p-Rb(S807/S811) | 134.09 | p-cJun(S73) | 83.10 | 2 | LOXIMVI-signal3 | C5 | |
| Vemurafenib | LOXIMVI | 0.1280 | uM | 24 | hr | | Ki-67 | 2570.00 | p-Rb(S807/S811) | 157.19 | p-cJun(S73) | 85.99 | 2 | LOXIMVI-signal3 | C6 | |
| Vemurafenib | LOXIMVI | 0.0512 | uM | 24 | hr | | Ki-67 | 2629.00 | p-Rb(S807/S811) | 170.98 | p-cJun(S73) | 89.13 | 2 | LOXIMVI-signal3 | C7 | |
| Vemurafenib | LOXIMVI | 0.0205 | uM | 24 | hr | | Ki-67 | 2858.70 | p-Rb(S807/S811) | 191.23 | p-cJun(S73) | 102.21 | 2 | LOXIMVI-signal3 | C8 | |
| Vemurafenib | LOXIMVI | 0.0082 | uM | 24 | hr | | Ki-67 | 2983.70 | p-Rb(S807/S811) | 203.05 | p-cJun(S73) | 109.97 | 2 | LOXIMVI-signal3 | C9 |