Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JNK-IN-8 | WM1552C | 0.0512 | uM | 24 | hr | | p27 Kip1 | 242.80 | p-Rb(S807/S811) | 108.49 | p-ERK(T202/Y204) | 267.00 | 2 | WM1552C-signal1 | E7 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p27 Kip1 | 231.78 | p-Rb(S807/S811) | 102.69 | p-ERK(T202/Y204) | 234.80 | 1 | WM1552C-signal1 | F10 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p27 Kip1 | 239.37 | p-Rb(S807/S811) | 107.35 | p-ERK(T202/Y204) | 253.29 | 1 | WM1552C-signal1 | F11 |
| Vemurafenib | WM1552C | JNK-IN-8 | 2.0000 | uM | 24 | hr | | p27 Kip1 | 478.70 | p-Rb(S807/S811) | 48.18 | p-ERK(T202/Y204) | 22.45 | 1 | WM1552C-signal1 | F3 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p27 Kip1 | 428.03 | p-Rb(S807/S811) | 51.23 | p-ERK(T202/Y204) | 26.59 | 1 | WM1552C-signal1 | F4 |
| Vemurafenib | WM1552C | 0.0033 | uM | 24 | hr | | p27 Kip1 | 246.89 | p-Rb(S807/S811) | 106.93 | p-ERK(T202/Y204) | 243.94 | 1 | WM1552C-signal1 | B10 | |
| Vemurafenib | WM1552C | 0.0000 | uM | 24 | hr | | p27 Kip1 | 243.77 | p-Rb(S807/S811) | 107.70 | p-ERK(T202/Y204) | 254.74 | 1 | WM1552C-signal1 | B11 | |
| Vemurafenib | WM1552C | 2.0000 | uM | 24 | hr | | p27 Kip1 | 473.39 | p-Rb(S807/S811) | 42.61 | p-ERK(T202/Y204) | 22.62 | 1 | WM1552C-signal1 | B3 | |
| Vemurafenib | WM1552C | 0.8000 | uM | 24 | hr | | p27 Kip1 | 442.40 | p-Rb(S807/S811) | 51.64 | p-ERK(T202/Y204) | 26.95 | 1 | WM1552C-signal1 | B4 | |
| Vemurafenib | WM1552C | 0.0512 | uM | 24 | hr | | p27 Kip1 | 269.92 | p-Rb(S807/S811) | 94.99 | p-ERK(T202/Y204) | 160.06 | 1 | WM1552C-signal1 | B7 | |
| Vemurafenib | WM1552C | 0.0205 | uM | 24 | hr | | p27 Kip1 | 252.92 | p-Rb(S807/S811) | 100.14 | p-ERK(T202/Y204) | 207.93 | 1 | WM1552C-signal1 | B8 | |
| Vemurafenib | WM1552C | 0.0033 | uM | 24 | hr | | p27 Kip1 | 240.73 | p-Rb(S807/S811) | 101.89 | p-ERK(T202/Y204) | 242.12 | 2 | WM1552C-signal1 | C10 | |
| Vemurafenib | WM1552C | 0.0000 | uM | 24 | hr | | p27 Kip1 | 244.71 | p-Rb(S807/S811) | 105.59 | p-ERK(T202/Y204) | 259.12 | 2 | WM1552C-signal1 | C11 | |
| Vemurafenib | WM1552C | 0.3200 | uM | 24 | hr | | p27 Kip1 | 349.70 | p-Rb(S807/S811) | 71.79 | p-ERK(T202/Y204) | 64.17 | 2 | WM1552C-signal1 | C5 | |
| Vemurafenib | WM1552C | 0.1280 | uM | 24 | hr | | p27 Kip1 | 271.43 | p-Rb(S807/S811) | 88.61 | p-ERK(T202/Y204) | 136.09 | 2 | WM1552C-signal1 | C6 | |
| Vemurafenib | WM1552C | 0.0205 | uM | 24 | hr | | p27 Kip1 | 249.99 | p-Rb(S807/S811) | 102.20 | p-ERK(T202/Y204) | 212.75 | 2 | WM1552C-signal1 | C8 | |
| Vemurafenib | WM1552C | 0.0082 | uM | 24 | hr | | p27 Kip1 | 241.99 | p-Rb(S807/S811) | 106.90 | p-ERK(T202/Y204) | 245.11 | 2 | WM1552C-signal1 | C9 | |
| JNK-IN-8 | WM1552C | 5.0000 | uM | 24 | hr | | p27 Kip1 | 304.56 | p-Rb(S807/S811) | 111.24 | p-ERK(T202/Y204) | 317.45 | 1 | WM1552C-signal1 | D2 | |
| JNK-IN-8 | WM1552C | 2.0000 | uM | 24 | hr | | p27 Kip1 | 258.20 | p-Rb(S807/S811) | 113.91 | p-ERK(T202/Y204) | 277.27 | 1 | WM1552C-signal1 | D3 | |
| JNK-IN-8 | WM1552C | 0.3200 | uM | 24 | hr | | p27 Kip1 | 235.99 | p-Rb(S807/S811) | 105.87 | p-ERK(T202/Y204) | 263.93 | 1 | WM1552C-signal1 | D5 | |
| JNK-IN-8 | WM1552C | 0.1280 | uM | 24 | hr | | p27 Kip1 | 241.67 | p-Rb(S807/S811) | 111.54 | p-ERK(T202/Y204) | 273.53 | 1 | WM1552C-signal1 | D6 | |
| JNK-IN-8 | WM1552C | 0.0000 | uM | 24 | hr | | p27 Kip1 | 241.45 | p-Rb(S807/S811) | 105.78 | p-ERK(T202/Y204) | 247.44 | 2 | WM1552C-signal1 | E11 | |
| JNK-IN-8 | WM1552C | 5.0000 | uM | 24 | hr | | p27 Kip1 | 313.64 | p-Rb(S807/S811) | 105.04 | p-ERK(T202/Y204) | 304.05 | 2 | WM1552C-signal1 | E2 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0082 | uM | 24 | hr | | p27 Kip1 | 256.65 | p-Rb(S807/S811) | 104.44 | p-ERK(T202/Y204) | 246.25 | 1 | WM1552C-signal1 | F9 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p27 Kip1 | 248.11 | p-Rb(S807/S811) | 100.68 | p-ERK(T202/Y204) | 212.80 | 1 | WM1552C-signal1 | F8 |