Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
AZ-628 WM-115 3.1600
uM
 72
hr
 1520 1204 0.1042 0.0874 0.7921 0.8202 3
AZ-628 WM-115 3.1600
uM
 72
hr
 1146 960 0.0614 0.0874 0.8377 0.8202 1
AZ-628 WM-115 3.1600
uM
 72
hr
 1633 1278 0.1171 0.0874 0.7826 0.8202 4
Vemurafenib MMAC-SF 3.1600
uM
 72
hr
 1123 713 0.1193 0.0882 0.6349 0.6920 3
Vemurafenib MMAC-SF 3.1600
uM
 72
hr
 973 694 0.0812 0.0882 0.7133 0.6920 2
Vemurafenib MMAC-SF 3.1600
uM
 72
hr
 874 626 0.0721 0.0882 0.7163 0.6920 1
Vemurafenib MMAC-SF 3.1600
uM
 72
hr
 931 655 0.0803 0.0882 0.7035 0.6920 4
Vemurafenib C32 3.1600
uM
 48
hr
 1342 1153 0.0920 0.1016 0.8592 0.8624 2
Vemurafenib C32 3.1600
uM
 48
hr
 1537 1306 0.1124 0.1016 0.8497 0.8624 3
Vemurafenib C32 3.1600
uM
 48
hr
 1499 1332 0.0813 0.1016 0.8886 0.8624 1
Vemurafenib C32 3.1600
uM
 48
hr
 1677 1429 0.1207 0.1016 0.8521 0.8624 4
AZ-628 C32 1.0000
uM
 48
hr
 1468 1265 0.0988 0.1086 0.8617 0.8467 3
AZ-628 C32 1.0000
uM
 48
hr
 1469 1230 0.1163 0.1086 0.8373 0.8467 4
AZ-628 C32 1.0000
uM
 48
hr
 1504 1277 0.1105 0.1086 0.8491 0.8467 1
AZ-628 C32 1.0000
uM
 48
hr
 1387 1163 0.1090 0.1086 0.8385 0.8467 2
Selumetinib C32 1.0000
uM
 72
hr
 1176 818 0.1563 0.1124 0.6956 0.7591 4
Selumetinib C32 1.0000
uM
 72
hr
 978 755 0.0974 0.1124 0.7720 0.7591 3
Selumetinib C32 1.0000
uM
 72
hr
 1071 807 0.1153 0.1124 0.7535 0.7591 2
Selumetinib C32 1.0000
uM
 72
hr
 1001 816 0.0808 0.1124 0.8152 0.7591 1
Vemurafenib COLO 858 3.1600
uM
 72
hr
 1334 952 0.1388 0.1269 0.7136 0.7234 3
Vemurafenib COLO 858 3.1600
uM
 72
hr
 1176 892 0.1032 0.1269 0.7585 0.7234 2
Vemurafenib COLO 858 3.1600
uM
 72
hr
 1205 867 0.1228 0.1269 0.7195 0.7234 1
Vemurafenib COLO 858 3.1600
uM
 72
hr
 1319 926 0.1428 0.1269 0.7021 0.7234 4
Selumetinib C32 3.1600
uM
 48
hr
 1431 1172 0.1260 0.1270 0.8190 0.8303 3
Selumetinib C32 3.1600
uM
 48
hr
 1702 1393 0.1504 0.1270 0.8185 0.8303 4