Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SB590885 | K2 | 1.0000 | uM | 24 | hr | 2523 | 15 | 1.4750 | 1.0860 | 0.0059 | 0.0129 | 1 |
| SB590885 | K2 | 1.0000 | uM | 24 | hr | 1194 | 24 | 0.6881 | 1.0860 | 0.0201 | 0.0129 | 4 |
| PLX-4720 | MZ7-mel | 0.0032 | uM | 24 | hr | 1396 | 15 | 1.0462 | 1.0184 | 0.0107 | 0.0130 | 1 |
| PLX-4720 | MZ7-mel | 0.0032 | uM | 24 | hr | 1447 | 14 | 1.0856 | 1.0184 | 0.0097 | 0.0130 | 2 |
| PLX-4720 | MZ7-mel | 0.0032 | uM | 24 | hr | 1331 | 23 | 0.9909 | 1.0184 | 0.0173 | 0.0130 | 3 |
| PLX-4720 | MZ7-mel | 0.0316 | uM | 48 | hr | 3849 | 36 | 1.1805 | 1.0185 | 0.0094 | 0.0130 | 1 |
| Selumetinib | MZ7-mel | 0.1000 | uM | 24 | hr | 1500 | 18 | 1.1227 | 1.0706 | 0.0120 | 0.0130 | 1 |
| Selumetinib | MZ7-mel | 0.1000 | uM | 24 | hr | 1409 | 23 | 1.0500 | 1.0706 | 0.0163 | 0.0130 | 4 |
| Selumetinib | MZ7-mel | 0.1000 | uM | 24 | hr | 1477 | 15 | 1.1076 | 1.0706 | 0.0102 | 0.0130 | 2 |
| Selumetinib | MZ7-mel | 0.1000 | uM | 24 | hr | 1341 | 18 | 1.0023 | 1.0706 | 0.0134 | 0.0130 | 3 |
| PLX-4720 | MZ7-mel | 0.0316 | uM | 48 | hr | 3057 | 21 | 0.9399 | 1.0185 | 0.0069 | 0.0130 | 2 |
| PLX-4720 | MZ7-mel | 0.0316 | uM | 48 | hr | 3070 | 47 | 0.9359 | 1.0185 | 0.0153 | 0.0130 | 3 |
| PLX-4720 | MZ7-mel | 0.0316 | uM | 48 | hr | 3355 | 68 | 1.0176 | 1.0185 | 0.0203 | 0.0130 | 4 |
| PLX-4720 | MZ7-mel | 0.0032 | uM | 24 | hr | 1273 | 18 | 0.9508 | 1.0184 | 0.0141 | 0.0130 | 4 |
| Vemurafenib | MZ7-mel | 0.0100 | uM | 24 | hr | 1775 | 34 | 1.3189 | 1.1080 | 0.0192 | 0.0131 | 1 |
| Vemurafenib | MZ7-mel | 0.0100 | uM | 24 | hr | 1159 | 7 | 0.8727 | 1.1080 | 0.0060 | 0.0131 | 3 |
| Vemurafenib | MZ7-mel | 0.0100 | uM | 24 | hr | 1249 | 19 | 0.9318 | 1.1080 | 0.0152 | 0.0131 | 4 |
| Vemurafenib | MZ7-mel | 0.0100 | uM | 24 | hr | 1748 | 21 | 1.3083 | 1.1080 | 0.0120 | 0.0131 | 2 |
| AZ-628 | MZ7-mel | 0.0032 | uM | 24 | hr | 1402 | 13 | 1.0523 | 1.0250 | 0.0093 | 0.0132 | 1 |
| AZ-628 | MZ7-mel | 0.0032 | uM | 24 | hr | 1342 | 26 | 0.9970 | 1.0250 | 0.0194 | 0.0132 | 4 |
| AZ-628 | MZ7-mel | 0.0032 | uM | 24 | hr | 1288 | 9 | 0.9689 | 1.0250 | 0.0070 | 0.0132 | 3 |
| AZ-628 | MZ7-mel | 0.0032 | uM | 24 | hr | 1453 | 25 | 1.0818 | 1.0250 | 0.0172 | 0.0132 | 2 |
| Selumetinib | MZ7-mel | 0.0100 | uM | 24 | hr | 1667 | 30 | 1.2402 | 1.1333 | 0.0180 | 0.0133 | 1 |
| Selumetinib | MZ7-mel | 0.0100 | uM | 24 | hr | 1430 | 11 | 1.0750 | 1.1333 | 0.0077 | 0.0133 | 4 |
| Selumetinib | MZ7-mel | 0.0100 | uM | 24 | hr | 1345 | 12 | 1.0098 | 1.1333 | 0.0089 | 0.0133 | 3 |