Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
Selumetinib WM-115 3.1600
uM
 24
hr
 378 71 0.5863 0.7277 0.1878 0.1433 1
AZ-628 WM-115 1.0000
uM
 24
hr
 382 53 0.6283 0.8699 0.1387 0.1346 2
Selumetinib WM-115 1.0000
uM
 24
hr
 386 42 0.6570 0.8900 0.1088 0.1020 2
WM-115 0.0000
uM
 24
hr
 387 29 0.6837 0.0749 2
PLX-4720 WM-115 0.0032
uM
 48
hr
 390 18 0.7510 1.2547 0.0462 0.0421 4
Selumetinib WM-115 3.1600
uM
 48
hr
 395 90 0.6158 0.5920 0.2279 0.2687 3
WM-115 0.0000
uM
 24
hr
 396 11 0.7353 0.0278 2
Vemurafenib WM-115 0.0032
uM
 48
hr
 398 27 0.7490 1.0448 0.0678 0.0621 3
WM-115 0.0000
uM
 48
hr
 406 16 0.7874 0.0394 2
PLX-4720 WM-115 3.1600
uM
 48
hr
 406 51 0.7167 0.7919 0.1256 0.1219 4
AZ-628 WM-115 1.0000
uM
 48
hr
 409 135 0.5532 0.6582 0.3301 0.3114 3
Selumetinib WM-115 3.1600
uM
 48
hr
 410 123 0.5794 0.5920 0.3000 0.2687 1
WM-115 0.0000
uM
 24
hr
 415 24 0.7468 0.0578 1
AZ-628 WM-115 0.0100
uM
 48
hr
 419 27 0.7914 1.1906 0.0644 0.0498 3
Selumetinib WM-115 0.0100
uM
 48
hr
 420 17 0.8136 1.3870 0.0405 0.0343 4
AZ-628 WM-115 1.0000
uM
 48
hr
 421 150 0.5471 0.6582 0.3563 0.3114 4
SB590885 WM-115 1.0000
uM
 48
hr
 422 57 0.7369 0.9721 0.1351 0.1007 3
PLX-4720 WM-115 3.1600
uM
 48
hr
 425 57 0.7430 0.7919 0.1341 0.1219 3
Selumetinib WM-115 3.1600
uM
 24
hr
 432 62 0.7067 0.7277 0.1435 0.1433 3
WM-115 0.0000
uM
 24
hr
 433 15 0.7983 0.0346 2
WM-115 0.0000
uM
 48
hr
 438 24 0.8358 0.0548 3
Vemurafenib WM-115 0.3160
uM
 24
hr
 439 15 0.8098 1.1741 0.0342 0.0444 2
AZ-628 WM-115 0.0032
uM
 48
hr
 441 17 0.8560 1.0559 0.0385 0.0302 4
WM-115 0.0000
uM
 24
hr
 441 42 0.7620 0.0952 4
AZ-628 WM-115 3.1600
uM
 24
hr
 446 130 0.6035 0.9459 0.2915 0.2024 1