Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
WM-115 0.0000
uM
 48
hr
 693 36 1.3264 0.0519 2
PLX-4720 SKMEL28 1.0000
uM
 72
hr
 694 22 0.5041 0.4583 0.0317 0.0372 4
Vemurafenib SKMEL28 1.0000
uM
 72
hr
 694 29 0.4988 0.4910 0.0418 0.0399 4
Vemurafenib WM-115 0.1000
uM
 24
hr
 696 28 1.2758 1.1793 0.0402 0.0385 3
PLX-4720 K2 1.0000
uM
 24
hr
 696 51 0.3793 0.6205 0.0733 0.0503 3
AZ-628 WM-115 0.1000
uM
 48
hr
 698 43 1.3224 1.3072 0.0616 0.0517 4
SB590885 WM-115 0.0032
uM
 24
hr
 699 36 1.2662 1.0581 0.0515 0.0434 1
SB590885 WM-115 3.1600
uM
 24
hr
 703 48 1.2510 1.2839 0.0683 0.0958 4
Vemurafenib K2 3.1600
uM
 24
hr
 703 126 0.3394 0.5895 0.1792 0.1831 3
WM-115 0.0000
uM
 24
hr
 705 32 1.2853 0.0454 3
PLX-4720 WM-115 0.0316
uM
 24
hr
 705 36 1.2777 1.4863 0.0511 0.0513 1
Selumetinib WM-115 0.0100
uM
 24
hr
 707 44 1.2662 1.2724 0.0622 0.0509 4
AZ-628 WM-115 0.0032
uM
 24
hr
 712 35 1.2930 1.1922 0.0492 0.0464 2
Selumetinib WM-115 0.1000
uM
 24
hr
 713 25 1.3140 1.2715 0.0351 0.0423 4
PLX-4720 WM-115 1.0000
uM
 48
hr
 714 37 1.3668 1.2446 0.0518 0.0466 1
SB590885 SKMEL28 3.1600
uM
 72
hr
 714 158 0.4171 0.3728 0.2213 0.2588 3
WM-115 0.0000
uM
 24
hr
 715 31 1.3063 0.0434 3
AZ-628 SKMEL28 0.1000
uM
 72
hr
 715 16 0.5243 0.5264 0.0224 0.0319 4
AZ-628 WM-115 0.0032
uM
 24
hr
 717 30 1.3121 1.1922 0.0418 0.0464 4
WM-115 0.0000
uM
 24
hr
 717 36 1.3006 0.0502 3
AZ-628 SKMEL28 1.0000
uM
 72
hr
 717 81 0.4771 0.4893 0.1130 0.1068 1
Selumetinib SKMEL28 1.0000
uM
 72
hr
 719 77 0.4816 0.4189 0.1071 0.1114 2
WM-115 0.0000
uM
 48
hr
 719 25 1.4011 0.0348 2
PLX-4720 WM-115 0.0316
uM
 48
hr
 720 30 1.3930 1.3188 0.0417 0.0356 3
PLX-4720 WM-115 0.3160
uM
 48
hr
 721 27 1.4011 1.6676 0.0374 0.0333 3