Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | WM-115 | 0.0100 | uM | 24 | hr | 670 | 16 | 1.2490 | 1.2046 | 0.0239 | 0.0451 | 2 |
| AZ-628 | SKMEL28 | 0.1000 | uM | 72 | hr | 671 | 17 | 0.4906 | 0.5264 | 0.0253 | 0.0319 | 2 |
| SB590885 | SKMEL28 | 3.1600 | uM | 72 | hr | 673 | 176 | 0.3728 | 0.3728 | 0.2615 | 0.2588 | 1 |
| Selumetinib | K2 | 0.3160 | uM | 24 | hr | 674 | 22 | 0.3835 | 0.4918 | 0.0326 | 0.0266 | 4 |
| WM-115 | 0.0000 | uM | 48 | hr | 676 | 20 | 1.3244 | 0.0296 | 1 | |||
| PLX-4720 | WM-115 | 0.0032 | uM | 24 | hr | 677 | 28 | 1.2395 | 1.1430 | 0.0414 | 0.0488 | 1 |
| AZ-628 | WM-115 | 3.1600 | uM | 24 | hr | 678 | 81 | 1.1402 | 0.9459 | 0.1195 | 0.2024 | 3 |
| Vemurafenib | WM-115 | 0.0032 | uM | 24 | hr | 680 | 25 | 1.2510 | 1.1746 | 0.0368 | 0.0555 | 2 |
| PLX-4720 | WM-115 | 0.1000 | uM | 24 | hr | 680 | 29 | 1.2433 | 1.4443 | 0.0426 | 0.0369 | 2 |
| AZ-628 | SKMEL28 | 0.3160 | uM | 72 | hr | 683 | 37 | 0.4846 | 0.5071 | 0.0542 | 0.0526 | 2 |
| PLX-4720 | WM-115 | 0.0032 | uM | 24 | hr | 683 | 41 | 1.2261 | 1.1430 | 0.0600 | 0.0488 | 4 |
| AZ-628 | WM-115 | 0.0100 | uM | 48 | hr | 685 | 21 | 1.3405 | 1.1906 | 0.0307 | 0.0498 | 2 |
| AZ-628 | WM-115 | 0.0316 | uM | 48 | hr | 685 | 27 | 1.3284 | 1.4692 | 0.0394 | 0.0357 | 4 |
| Vemurafenib | WM-115 | 3.1600 | uM | 24 | hr | 686 | 41 | 1.2319 | 1.2381 | 0.0598 | 0.0792 | 3 |
| SB590885 | SKMEL28 | 3.1600 | uM | 72 | hr | 687 | 162 | 0.3938 | 0.3728 | 0.2358 | 0.2588 | 4 |
| PLX-4720 | WM-115 | 1.0000 | uM | 24 | hr | 688 | 43 | 1.2319 | 1.0218 | 0.0625 | 0.0643 | 3 |
| Vemurafenib | WM-115 | 0.0316 | uM | 48 | hr | 688 | 27 | 1.3345 | 1.2406 | 0.0392 | 0.0424 | 1 |
| Selumetinib | SKMEL28 | 0.1000 | uM | 72 | hr | 689 | 23 | 0.4996 | 0.5435 | 0.0334 | 0.0370 | 3 |
| AZ-628 | SKMEL28 | 1.0000 | uM | 72 | hr | 689 | 71 | 0.4636 | 0.4893 | 0.1031 | 0.1068 | 3 |
| PLX-4720 | WM-115 | 0.0316 | uM | 48 | hr | 689 | 22 | 1.3466 | 1.3188 | 0.0319 | 0.0356 | 2 |
| Selumetinib | WM-115 | 0.0032 | uM | 48 | hr | 690 | 30 | 1.3325 | 1.0175 | 0.0435 | 0.0459 | 2 |
| PLX-4720 | WM-115 | 1.0000 | uM | 24 | hr | 691 | 38 | 1.2471 | 1.0218 | 0.0550 | 0.0643 | 1 |
| WM-115 | 0.0000 | uM | 24 | hr | 692 | 25 | 1.2739 | 0.0361 | 1 | |||
| Selumetinib | SKMEL28 | 1.0000 | uM | 72 | hr | 693 | 67 | 0.4696 | 0.4189 | 0.0967 | 0.1114 | 4 |
| AZ-628 | WM-115 | 0.0316 | uM | 24 | hr | 693 | 40 | 1.2471 | 1.5054 | 0.0577 | 0.0535 | 2 |