Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selumetinib | COLO 858 | 0.0100 | uM | 24 | hr | 2776 | 117 | 0.8882 | 1.0900 | 0.0421 | 0.0441 | 4 |
| Selumetinib | COLO 858 | 0.0100 | uM | 24 | hr | 2632 | 117 | 0.8401 | 1.0900 | 0.0445 | 0.0441 | 3 |
| SB590885 | C32 | 1.0000 | uM | 24 | hr | 1840 | 455 | 0.8008 | 0.8421 | 0.2473 | 0.2404 | 3 |
| SB590885 | COLO 858 | 0.0032 | uM | 24 | hr | 3566 | 150 | 1.1411 | 0.8658 | 0.0421 | 0.0451 | 1 |
| SB590885 | COLO 858 | 0.0032 | uM | 24 | hr | 3890 | 200 | 1.2326 | 0.8658 | 0.0514 | 0.0451 | 2 |
| SB590885 | COLO 858 | 0.0032 | uM | 24 | hr | 1735 | 72 | 0.5555 | 0.8658 | 0.0415 | 0.0451 | 3 |
| SB590885 | COLO 858 | 0.0032 | uM | 24 | hr | 1675 | 76 | 0.5341 | 0.8658 | 0.0454 | 0.0451 | 4 |
| Selumetinib | C32 | 0.0032 | uM | 24 | hr | 2271 | 188 | 1.2043 | 1.0228 | 0.0828 | 0.0878 | 2 |
| Selumetinib | C32 | 0.0032 | uM | 24 | hr | 1584 | 144 | 0.8326 | 1.0228 | 0.0909 | 0.0878 | 3 |
| SB590885 | WM-115 | 0.0316 | uM | 24 | hr | 965 | 35 | 1.7762 | 1.3555 | 0.0363 | 0.0512 | 4 |
| Selumetinib | C32 | 0.0032 | uM | 24 | hr | 1924 | 220 | 0.9852 | 1.0228 | 0.1144 | 0.0878 | 4 |
| SB590885 | COLO 858 | 0.0316 | uM | 24 | hr | 4683 | 198 | 1.4982 | 1.1972 | 0.0423 | 0.0423 | 2 |
| SB590885 | C32 | 1.0000 | uM | 24 | hr | 1969 | 511 | 0.8430 | 0.8421 | 0.2595 | 0.2404 | 4 |
| SB590885 | COLO 858 | 0.0316 | uM | 24 | hr | 4716 | 182 | 1.5145 | 1.1972 | 0.0386 | 0.0423 | 1 |
| SB590885 | COLO 858 | 0.0316 | uM | 24 | hr | 2848 | 142 | 0.9039 | 1.1972 | 0.0499 | 0.0423 | 3 |
| SB590885 | COLO 858 | 0.0100 | uM | 24 | hr | 4351 | 191 | 1.3896 | 1.2055 | 0.0439 | 0.0421 | 1 |
| SB590885 | COLO 858 | 0.0100 | uM | 24 | hr | 4427 | 181 | 1.4183 | 1.2055 | 0.0409 | 0.0421 | 2 |
| SB590885 | COLO 858 | 0.0100 | uM | 24 | hr | 2526 | 105 | 0.8087 | 1.2055 | 0.0416 | 0.0421 | 3 |
| SB590885 | COLO 858 | 0.0100 | uM | 24 | hr | 4 | ||||||
| SB590885 | C32 | 0.0100 | uM | 24 | hr | 2109 | 263 | 1.0673 | 1.0475 | 0.1247 | 0.1377 | 4 |
| Selumetinib | COLO 858 | 0.3160 | uM | 24 | hr | 4059 | 319 | 1.2493 | 1.0085 | 0.0786 | 0.0830 | 1 |
| Selumetinib | COLO 858 | 0.3160 | uM | 24 | hr | 4087 | 312 | 1.2610 | 1.0085 | 0.0763 | 0.0830 | 2 |
| Selumetinib | COLO 858 | 1.0000 | uM | 24 | hr | 3878 | 512 | 1.1244 | 0.9366 | 0.1320 | 0.1371 | 1 |
| SB590885 | WM-115 | 1.0000 | uM | 24 | hr | 649 | 74 | 1.0982 | 1.1516 | 0.1140 | 0.0874 | 1 |
| SB590885 | WM-115 | 0.3160 | uM | 24 | hr | 891 | 43 | 1.6196 | 1.3541 | 0.0483 | 0.0461 | 4 |