Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selumetinib | C32 | 0.0316 | uM | 24 | hr | 1852 | 297 | 0.8990 | 1.0009 | 0.1604 | 0.1442 | 1 |
| Selumetinib | C32 | 0.0316 | uM | 24 | hr | 2224 | 308 | 1.1078 | 1.0009 | 0.1385 | 0.1442 | 2 |
| Selumetinib | C32 | 0.0316 | uM | 24 | hr | 1959 | 249 | 0.9887 | 1.0009 | 0.1271 | 0.1442 | 3 |
| Selumetinib | C32 | 0.0316 | uM | 24 | hr | 2054 | 310 | 1.0083 | 1.0009 | 0.1509 | 0.1442 | 4 |
| SB590885 | COLO 858 | 0.1000 | uM | 24 | hr | 3881 | 216 | 1.2242 | 1.0049 | 0.0557 | 0.0572 | 2 |
| SB590885 | COLO 858 | 0.1000 | uM | 24 | hr | 2489 | 168 | 0.7753 | 1.0049 | 0.0675 | 0.0572 | 4 |
| SB590885 | COLO 858 | 0.3160 | uM | 24 | hr | 3906 | 310 | 1.2012 | 0.9462 | 0.0794 | 0.0792 | 1 |
| Selumetinib | C32 | 3.1600 | uM | 24 | hr | 2036 | 447 | 0.9187 | 0.8107 | 0.2196 | 0.2716 | 4 |
| SB590885 | COLO 858 | 0.3160 | uM | 24 | hr | 2335 | 193 | 0.7155 | 0.9462 | 0.0827 | 0.0792 | 4 |
| Selumetinib | C32 | 3.1600 | uM | 24 | hr | 1830 | 570 | 0.7285 | 0.8107 | 0.3115 | 0.2716 | 1 |
| Selumetinib | C32 | 3.1600 | uM | 24 | hr | 1874 | 601 | 0.7360 | 0.8107 | 0.3207 | 0.2716 | 2 |
| SB590885 | C32 | 0.0032 | uM | 24 | hr | 2021 | 240 | 1.0297 | 1.0722 | 0.1188 | 0.0901 | 1 |
| Selumetinib | C32 | 0.1000 | uM | 24 | hr | 1789 | 395 | 0.8060 | 0.8908 | 0.2208 | 0.2131 | 1 |
| Selumetinib | C32 | 0.1000 | uM | 24 | hr | 2033 | 467 | 0.9054 | 0.8908 | 0.2297 | 0.2131 | 2 |
| Selumetinib | C32 | 0.1000 | uM | 24 | hr | 1878 | 347 | 0.8852 | 0.8908 | 0.1848 | 0.2131 | 3 |
| Selumetinib | C32 | 0.1000 | uM | 24 | hr | 2136 | 464 | 0.9667 | 0.8908 | 0.2172 | 0.2131 | 4 |
| PLX-4720 | C32 | 1.0000 | uM | 24 | hr | 1949 | 537 | 0.8164 | 0.8236 | 0.2755 | 0.2452 | 2 |
| PLX-4720 | C32 | 1.0000 | uM | 24 | hr | 1814 | 427 | 0.8019 | 0.8236 | 0.2354 | 0.2452 | 3 |
| SB590885 | COLO 858 | 3.1600 | uM | 24 | hr | 3425 | 396 | 1.0118 | 0.8106 | 0.1156 | 0.1298 | 2 |
| PLX-4720 | C32 | 1.0000 | uM | 24 | hr | 1861 | 422 | 0.8320 | 0.8236 | 0.2268 | 0.2452 | 4 |
| SB590885 | C32 | 0.1000 | uM | 24 | hr | 2119 | 435 | 0.9736 | 1.0512 | 0.2053 | 0.1944 | 1 |
| SB590885 | C32 | 3.1600 | uM | 24 | hr | 1897 | 517 | 0.7979 | 0.7788 | 0.2725 | 0.2708 | 2 |
| Vemurafenib | C32 | 0.0032 | uM | 24 | hr | 1720 | 158 | 0.9031 | 0.9871 | 0.0919 | 0.0798 | 2 |
| Vemurafenib | COLO 858 | 0.3160 | uM | 24 | hr | 2475 | 156 | 0.7746 | 0.9158 | 0.0630 | 0.0538 | 4 |
| Vemurafenib | COLO 858 | 0.3160 | uM | 24 | hr | 1770 | 96 | 0.5592 | 0.9158 | 0.0542 | 0.0538 | 3 |