Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SB590885 | C32 | 1.0000 | uM | 24 | hr | 1840 | 455 | 0.8008 | 0.8421 | 0.2473 | 0.2404 | 3 |
| Selumetinib | C32 | 0.0032 | uM | 24 | hr | 1974 | 125 | 1.0690 | 1.0228 | 0.0633 | 0.0878 | 1 |
| Selumetinib | C32 | 0.0032 | uM | 24 | hr | 2271 | 188 | 1.2043 | 1.0228 | 0.0828 | 0.0878 | 2 |
| Selumetinib | C32 | 0.0032 | uM | 24 | hr | 1584 | 144 | 0.8326 | 1.0228 | 0.0909 | 0.0878 | 3 |
| Selumetinib | C32 | 0.0032 | uM | 24 | hr | 1924 | 220 | 0.9852 | 1.0228 | 0.1144 | 0.0878 | 4 |
| SB590885 | C32 | 1.0000 | uM | 24 | hr | 1969 | 511 | 0.8430 | 0.8421 | 0.2595 | 0.2404 | 4 |
| Selumetinib | C32 | 1.0000 | uM | 24 | hr | 1833 | 410 | 0.8227 | 0.8612 | 0.2237 | 0.2365 | 3 |
| Vemurafenib | C32 | 3.1600 | uM | 24 | hr | 1650 | 508 | 0.6603 | 0.6366 | 0.3079 | 0.3094 | 3 |
| SB590885 | C32 | 0.0100 | uM | 24 | hr | 2109 | 263 | 1.0673 | 1.0475 | 0.1247 | 0.1377 | 4 |
| Selumetinib | C32 | 0.0316 | uM | 24 | hr | 1852 | 297 | 0.8990 | 1.0009 | 0.1604 | 0.1442 | 1 |
| Selumetinib | C32 | 0.0316 | uM | 24 | hr | 1959 | 249 | 0.9887 | 1.0009 | 0.1271 | 0.1442 | 3 |
| Selumetinib | C32 | 0.0316 | uM | 24 | hr | 2224 | 308 | 1.1078 | 1.0009 | 0.1385 | 0.1442 | 2 |
| C32 | 0.0000 | uM | 24 | hr | 2058 | 210 | 1.0684 | 0.1020 | 1 | |||
| Selumetinib | C32 | 0.0100 | uM | 24 | hr | 1715 | 193 | 0.8800 | 1.0245 | 0.1125 | 0.1131 | 1 |
| Selumetinib | C32 | 0.0100 | uM | 24 | hr | 2015 | 239 | 1.0268 | 1.0245 | 0.1186 | 0.1131 | 2 |
| Selumetinib | C32 | 0.0100 | uM | 24 | hr | 2029 | 229 | 1.0407 | 1.0245 | 0.1129 | 0.1131 | 3 |
| Selumetinib | C32 | 0.0100 | uM | 24 | hr | 2232 | 242 | 1.1505 | 1.0245 | 0.1084 | 0.1131 | 4 |
| PLX-4720 | C32 | 0.3160 | uM | 24 | hr | 1982 | 341 | 0.9488 | 0.9421 | 0.1721 | 0.1737 | 2 |
| PLX-4720 | C32 | 0.3160 | uM | 24 | hr | 2025 | 391 | 0.9447 | 0.9421 | 0.1931 | 0.1737 | 3 |
| C32 | 0.0000 | uM | 24 | hr | 1691 | 148 | 0.8921 | 0.0875 | 2 | |||
| PLX-4720 | C32 | 0.3160 | uM | 24 | hr | 1910 | 314 | 0.9227 | 0.9421 | 0.1644 | 0.1737 | 4 |
| Selumetinib | C32 | 0.1000 | uM | 24 | hr | 1878 | 347 | 0.8852 | 0.8908 | 0.1848 | 0.2131 | 3 |
| SB590885 | C32 | 0.0032 | uM | 24 | hr | 2049 | 142 | 1.1026 | 1.0722 | 0.0693 | 0.0901 | 4 |
| Selumetinib | COLO 858 | 1.0000 | uM | 24 | hr | 2444 | 315 | 0.7112 | 0.9366 | 0.1289 | 0.1371 | 3 |
| Selumetinib | COLO 858 | 1.0000 | uM | 24 | hr | 4067 | 545 | 1.1765 | 0.9366 | 0.1340 | 0.1371 | 2 |