Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SB590885 | C32 | 0.0100 | uM | 24 | hr | 1984 | 303 | 0.9719 | 1.0475 | 0.1527 | 0.1377 | 1 |
| SB590885 | C32 | 0.3160 | uM | 48 | hr | 2033 | 401 | 0.7941 | 0.8577 | 0.1973 | 0.1894 | 1 |
| PLX-4720 | C32 | 0.3160 | uM | 24 | hr | 1973 | 326 | 0.9522 | 0.9421 | 0.1652 | 0.1737 | 1 |
| AZ-628 | C32 | 3.1600 | uM | 24 | hr | 2015 | 456 | 0.9014 | 0.8769 | 0.2263 | 0.2397 | 1 |
| PLX-4720 | C32 | 0.3160 | uM | 48 | hr | 1854 | 281 | 0.7654 | 0.8575 | 0.1516 | 0.1431 | 1 |
| SB590885 | C32 | 0.3160 | uM | 72 | hr | 1227 | 361 | 0.3781 | 0.4360 | 0.2942 | 0.2745 | 1 |
| SB590885 | C32 | 0.0316 | uM | 48 | hr | 2123 | 217 | 0.9274 | 1.0348 | 0.1022 | 0.0893 | 1 |
| PLX-4720 | C32 | 0.0100 | uM | 24 | hr | 1893 | 277 | 0.9343 | 1.0031 | 0.1463 | 0.1207 | 1 |
| Selumetinib | C32 | 0.0100 | uM | 24 | hr | 1715 | 193 | 0.8800 | 1.0245 | 0.1125 | 0.1131 | 1 |
| SB590885 | C32 | 1.0000 | uM | 24 | hr | 1866 | 424 | 0.8337 | 0.8421 | 0.2272 | 0.2404 | 1 |
| PLX-4720 | C32 | 0.3160 | uM | 72 | hr | 1393 | 337 | 0.4611 | 0.5161 | 0.2419 | 0.2146 | 1 |
| Selumetinib | C32 | 0.0100 | uM | 72 | hr | 2202 | 144 | 0.8985 | 0.9982 | 0.0654 | 0.0822 | 1 |
| SB590885 | C32 | 0.0032 | uM | 24 | hr | 2021 | 240 | 1.0297 | 1.0722 | 0.1188 | 0.0901 | 1 |
| SB590885 | C32 | 1.0000 | uM | 48 | hr | 1752 | 701 | 0.5114 | 0.5507 | 0.4001 | 0.3802 | 1 |
| SB590885 | C32 | 0.0316 | uM | 72 | hr | 2637 | 79 | 1.1168 | 1.0834 | 0.0300 | 0.0299 | 1 |
| PLX-4720 | C32 | 0.0032 | uM | 48 | hr | 2479 | 281 | 1.0695 | 1.1088 | 0.1134 | 0.0967 | 1 |
| SB590885 | C32 | 0.0100 | uM | 48 | hr | 2014 | 286 | 0.8408 | 1.0390 | 0.1420 | 0.1215 | 1 |
| SB590885 | C32 | 1.0000 | uM | 72 | hr | 1164 | 580 | 0.2550 | 0.2758 | 0.4983 | 0.4735 | 1 |
| PLX-4720 | C32 | 0.0100 | uM | 48 | hr | 1600 | 351 | 0.6077 | 0.9050 | 0.2194 | 0.1586 | 1 |
| PLX-4720 | C32 | 0.0316 | uM | 48 | hr | 1968 | 401 | 0.7625 | 0.9286 | 0.2038 | 0.1583 | 1 |
| SB590885 | C32 | 0.0032 | uM | 72 | hr | 2185 | 204 | 0.8649 | 1.0978 | 0.0934 | 0.0657 | 1 |
| SB590885 | C32 | 3.1600 | uM | 24 | hr | 1858 | 507 | 0.7811 | 0.7788 | 0.2729 | 0.2708 | 1 |
| SB590885 | C32 | 0.1000 | uM | 24 | hr | 2119 | 435 | 0.9736 | 1.0512 | 0.2053 | 0.1944 | 1 |
| Selumetinib | C32 | 0.1000 | uM | 72 | hr | 1681 | 151 | 0.6680 | 0.6980 | 0.0898 | 0.1075 | 1 |
| Selumetinib | C32 | 0.1000 | uM | 48 | hr | 2005 | 219 | 0.8690 | 0.9590 | 0.1092 | 0.1069 | 1 |