Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SB590885 | RVH-421 | 0.3160 | uM | 24 | hr | 1447 | 90 | 0.9817 | 1.0121 | 0.0622 | 0.0536 | 1 |
| Selumetinib | C32 | 0.0032 | uM | 24 | hr | 1974 | 125 | 1.0690 | 1.0228 | 0.0633 | 0.0878 | 1 |
| SB590885 | COLO 858 | 0.0316 | uM | 72 | hr | 2693 | 181 | 0.9124 | 0.9061 | 0.0672 | 0.0676 | 1 |
| SB590885 | RVH-421 | 0.3160 | uM | 72 | hr | 6332 | 273 | 0.6943 | 0.6412 | 0.0431 | 0.0408 | 1 |
| SB590885 | C32 | 0.0032 | uM | 24 | hr | 2021 | 240 | 1.0297 | 1.0722 | 0.1188 | 0.0901 | 1 |
| Selumetinib | C32 | 0.0032 | uM | 48 | hr | 2386 | 210 | 1.0588 | 1.2397 | 0.0880 | 0.0773 | 1 |
| PLX-4720 | C32 | 0.1000 | uM | 72 | hr | 2073 | 69 | 0.8750 | 0.9374 | 0.0333 | 0.0354 | 1 |
| Selumetinib | C32 | 0.0316 | uM | 72 | hr | 2088 | 86 | 0.8741 | 0.9520 | 0.0412 | 0.0406 | 1 |
| SB590885 | C32 | 1.0000 | uM | 48 | hr | 1752 | 701 | 0.5114 | 0.5507 | 0.4001 | 0.3802 | 1 |
| Selumetinib | C32 | 0.0032 | uM | 72 | hr | 1708 | 247 | 0.6379 | 0.8911 | 0.1446 | 0.1032 | 1 |
| Vemurafenib | C32 | 1.0000 | uM | 24 | hr | 2013 | 331 | 0.9725 | 0.9267 | 0.1644 | 0.1700 | 1 |
| SB590885 | COLO 858 | 0.1000 | uM | 72 | hr | 1700 | 123 | 0.5728 | 0.6054 | 0.0724 | 0.0770 | 1 |
| SB590885 | C32 | 0.0316 | uM | 72 | hr | 2637 | 79 | 1.1168 | 1.0834 | 0.0300 | 0.0299 | 1 |
| Selumetinib | C32 | 0.0100 | uM | 24 | hr | 1715 | 193 | 0.8800 | 1.0245 | 0.1125 | 0.1131 | 1 |
| PLX-4720 | C32 | 0.3160 | uM | 24 | hr | 1973 | 326 | 0.9522 | 0.9421 | 0.1652 | 0.1737 | 1 |
| Vemurafenib | C32 | 0.1000 | uM | 24 | hr | 2065 | 385 | 0.9713 | 0.9852 | 0.1864 | 0.1861 | 1 |
| Vemurafenib | C32 | 0.1000 | uM | 48 | hr | 2057 | 297 | 0.8564 | 0.9598 | 0.1444 | 0.1267 | 1 |
| Selumetinib | C32 | 0.0100 | uM | 48 | hr | 1636 | 224 | 0.6870 | 1.0942 | 0.1369 | 0.0963 | 1 |
| SB590885 | COLO 858 | 3.1600 | uM | 24 | hr | 3538 | 464 | 1.0268 | 0.8106 | 0.1312 | 0.1298 | 1 |
| SB590885 | COLO 858 | 3.1600 | uM | 48 | hr | 1722 | 511 | 0.2767 | 0.2774 | 0.2968 | 0.3405 | 1 |
| SB590885 | C32 | 0.0100 | uM | 48 | hr | 2014 | 286 | 0.8408 | 1.0390 | 0.1420 | 0.1215 | 1 |
| Selumetinib | C32 | 0.0100 | uM | 72 | hr | 2202 | 144 | 0.8985 | 0.9982 | 0.0654 | 0.0822 | 1 |
| PLX-4720 | C32 | 0.3160 | uM | 48 | hr | 1854 | 281 | 0.7654 | 0.8575 | 0.1516 | 0.1431 | 1 |
| PLX-4720 | RVH-421 | 0.0032 | uM | 48 | hr | 2325 | 113 | 1.1558 | 1.0326 | 0.0486 | 0.0464 | 1 |
| PLX-4720 | RVH-421 | 0.0032 | uM | 24 | hr | 1455 | 83 | 0.9925 | 0.9321 | 0.0570 | 0.0586 | 1 |