Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
Selumetinib C32 1.0000
uM
 72
hr
 1001 816 0.0808 0.1124 0.8152 0.7591 1
SB590885 C32 0.3160
uM
 72
hr
 1227 361 0.3781 0.4360 0.2942 0.2745 1
AZ-628 C32 1.0000
uM
 24
hr
 2103 810 0.7476 0.7571 0.3852 0.3378 1
C32 0.0000
uM
 48
hr
 2240 384 0.9031 0.1714 1
Vemurafenib COLO 858 0.1000
uM
 48
hr
 4064 201 0.8826 0.9327 0.0495 0.0491 1
SB590885 C32 0.0316
uM
 48
hr
 2123 217 0.9274 1.0348 0.1022 0.0893 1
AZ-628 C32 1.0000
uM
 48
hr
 1504 1277 0.1105 0.1086 0.8491 0.8467 1
PLX-4720 C32 0.0316
uM
 72
hr
 2777 157 1.1439 1.0994 0.0565 0.0684 1
Vemurafenib COLO 858 0.3160
uM
 72
hr
 1843 120 0.6259 0.6802 0.0651 0.0687 1
Vemurafenib COLO 858 1.0000
uM
 72
hr
 1495 369 0.4090 0.3928 0.2468 0.2502 1
AZ-628 C32 1.0000
uM
 72
hr
 1127 993 0.0585 0.0591 0.8811 0.8863 1
Vemurafenib COLO 858 3.1600
uM
 48
hr
 1625 663 0.2198 0.2150 0.4080 0.4525 1
Vemurafenib COLO 858 3.1600
uM
 72
hr
 1205 867 0.1228 0.1269 0.7195 0.7234 1
Selumetinib C32 3.1600
uM
 48
hr
 1464 1224 0.1168 0.1270 0.8361 0.8303 1
AZ-628 C32 3.1600
uM
 24
hr
 2015 456 0.9014 0.8769 0.2263 0.2397 1
PLX-4720 C32 0.1000
uM
 24
hr
 1907 284 0.9384 1.0076 0.1489 0.1525 1
Selumetinib C32 3.1600
uM
 24
hr
 1830 570 0.7285 0.8107 0.3115 0.2716 1
SB590885 C32 1.0000
uM
 24
hr
 1866 424 0.8337 0.8421 0.2272 0.2404 1
AZ-628 C32 3.1600
uM
 48
hr
 1609 1466 0.0696 0.0749 0.9111 0.9051 1
C32 0.0000
uM
 72
hr
 2441 296 0.9365 0.1213 1
C32 0.0000
uM
 72
hr
 2479 286 0.9575 0.1154 1
C32 0.0000
uM
 72
hr
 2644 259 1.0413 0.0980 1
AZ-628 C32 3.1600
uM
 72
hr
 1046 997 0.0214 0.0269 0.9532 0.9414 1
COLO 858 0.0000
uM
 72
hr
 2994 245 0.9985 0.0818 1
COLO 858 0.0000
uM
 72
hr
 2941 261 0.9735 0.0887 1