Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
AZ-628 MZ7-mel 0.3160
uM
 48
hr
 1668 64 0.4966 0.5485 0.0384 0.0421 2
AZ-628 COLO 858 0.1000
uM
 48
hr
 2365 189 0.4972 0.4799 0.0799 0.1205 1
Selumetinib MZ7-mel 0.3160
uM
 48
hr
 1689 82 0.4975 0.5082 0.0485 0.0385 2
Vemurafenib RVH-421 3.1600
uM
 48
hr
 1075 121 0.4985 0.5028 0.1126 0.0864 1
Vemurafenib RVH-421 1.0000
uM
 72
hr
 4568 216 0.4987 0.5393 0.0473 0.0453 4
Vemurafenib SKMEL28 1.0000
uM
 72
hr
 694 29 0.4988 0.4910 0.0418 0.0399 4
Selumetinib SKMEL28 0.1000
uM
 72
hr
 689 23 0.4996 0.5435 0.0334 0.0370 3
Selumetinib WM1552C 0.3160
uM
 72
hr
 2882 301 0.5006 0.5260 0.1044 0.1044 4
PLX-4720 RVH-421 3.1600
uM
 48
hr
 1066 107 0.5011 0.5407 0.1004 0.0831 2
Vemurafenib C32 1.0000
uM
 48
hr
 1736 706 0.5012 0.5510 0.4067 0.4072 2
PLX-4720 RVH-421 3.1600
uM
 72
hr
 4620 239 0.5020 0.4833 0.0517 0.0617 4
Selumetinib COLO 858 0.0032
uM
 24
hr
 1585 80 0.5027 0.8441 0.0505 0.0501 4
Selumetinib MMAC-SF 0.0316
uM
 72
hr
 1785 55 0.5033 0.5628 0.0308 0.0318 1
AZ-628 MMAC-SF 0.1000
uM
 72
hr
 1940 210 0.5033 0.5190 0.1083 0.0830 3
Selumetinib RVH-421 3.1600
uM
 72
hr
 4854 456 0.5040 0.4879 0.0939 0.0977 2
PLX-4720 SKMEL28 1.0000
uM
 72
hr
 694 22 0.5041 0.4583 0.0317 0.0372 4
PLX-4720 WM1552C 3.1600
uM
 72
hr
 3028 426 0.5047 0.4966 0.1407 0.1295 2
AZ-628 RVH-421 0.1000
uM
 72
hr
 4570 164 0.5049 0.5796 0.0359 0.0442 3
AZ-628 WM-115 3.1600
uM
 48
hr
 372 121 0.5067 0.4240 0.3253 0.3788 1
AZ-628 WM1552C 0.3160
uM
 72
hr
 3070 457 0.5068 0.5552 0.1489 0.1343 4
AZ-628 MZ7-mel 0.0316
uM
 72
hr
 1278 61 0.5069 0.5863 0.0477 0.0428 3
AZ-628 SKMEL28 1.0000
uM
 72
hr
 759 83 0.5071 0.4893 0.1094 0.1068 2
Selumetinib COLO 858 0.1000
uM
 72
hr
 1509 112 0.5074 0.5449 0.0742 0.0769 1
Selumetinib RVH-421 0.3160
uM
 72
hr
 4671 239 0.5079 0.5657 0.0512 0.0438 3
PLX-4720 MMAC-SF 0.3160
uM
 72
hr
 1848 102 0.5079 0.5313 0.0552 0.0549 2