Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
Vemurafenib MMAC-SF 3.1600
uM
 72
hr
 973 694 0.0812 0.0882 0.7133 0.6920 2
Vemurafenib C32 3.1600
uM
 48
hr
 1499 1332 0.0813 0.1016 0.8886 0.8624 1
PLX-4720 C32 3.1600
uM
 72
hr
 820 631 0.0825 0.0669 0.7695 0.8134 2
AZ-628 C32 3.1600
uM
 48
hr
 1739 1565 0.0847 0.0749 0.8999 0.9051 2
PLX-4720 C32 3.1600
uM
 72
hr
 778 581 0.0860 0.0669 0.7468 0.8134 4
Selumetinib C32 3.1600
uM
 72
hr
 1114 913 0.0878 0.0615 0.8196 0.8621 4
Vemurafenib C32 3.1600
uM
 48
hr
 1342 1153 0.0920 0.1016 0.8592 0.8624 2
Selumetinib C32 1.0000
uM
 72
hr
 978 755 0.0974 0.1124 0.7720 0.7591 3
AZ-628 C32 1.0000
uM
 48
hr
 1468 1265 0.0988 0.1086 0.8617 0.8467 3
Vemurafenib COLO 858 3.1600
uM
 72
hr
 1176 892 0.1032 0.1269 0.7585 0.7234 2
AZ-628 WM-115 3.1600
uM
 72
hr
 1520 1204 0.1042 0.0874 0.7921 0.8202 3
AZ-628 C32 1.0000
uM
 48
hr
 1387 1163 0.1090 0.1086 0.8385 0.8467 2
AZ-628 C32 1.0000
uM
 48
hr
 1504 1277 0.1105 0.1086 0.8491 0.8467 1
Vemurafenib C32 3.1600
uM
 48
hr
 1537 1306 0.1124 0.1016 0.8497 0.8624 3
Selumetinib C32 3.1600
uM
 48
hr
 1550 1314 0.1148 0.1270 0.8477 0.8303 2
Selumetinib C32 1.0000
uM
 72
hr
 1071 807 0.1153 0.1124 0.7535 0.7591 2
AZ-628 C32 1.0000
uM
 48
hr
 1469 1230 0.1163 0.1086 0.8373 0.8467 4
Selumetinib C32 3.1600
uM
 48
hr
 1464 1224 0.1168 0.1270 0.8361 0.8303 1
AZ-628 WM-115 3.1600
uM
 72
hr
 1633 1278 0.1171 0.0874 0.7826 0.8202 4
Vemurafenib MMAC-SF 3.1600
uM
 72
hr
 1123 713 0.1193 0.0882 0.6349 0.6920 3
AZ-628 WM-115 1.0000
uM
 72
hr
 1455 1092 0.1197 0.1723 0.7505 0.6442 2
PLX-4720 C32 3.1600
uM
 48
hr
 1321 1073 0.1207 0.1550 0.8123 0.7840 2
Vemurafenib C32 3.1600
uM
 48
hr
 1677 1429 0.1207 0.1016 0.8521 0.8624 4
Vemurafenib COLO 858 3.1600
uM
 72
hr
 1205 867 0.1228 0.1269 0.7195 0.7234 1
Selumetinib C32 3.1600
uM
 48
hr
 1431 1172 0.1260 0.1270 0.8190 0.8303 3