Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
Selumetinib K2 0.3160
uM
 24
hr
 619 22 0.3511 0.4918 0.0355 0.0266 3
AZ-628 MMAC-SF 0.3160
uM
 72
hr
 1558 348 0.3520 0.3668 0.2234 0.2255 3
Selumetinib C32 1.0000
uM
 48
hr
 1668 944 0.3523 0.3220 0.5660 0.5982 3
Vemurafenib MZ7-mel 1.0000
uM
 72
hr
 939 92 0.3528 0.3670 0.0980 0.1033 2
AZ-628 COLO 858 0.3160
uM
 48
hr
 1985 439 0.3532 0.3684 0.2212 0.2211 3
PLX-4720 SKMEL28 3.1600
uM
 72
hr
 528 56 0.3541 0.3891 0.1061 0.1047 1
SB590885 C32 3.1600
uM
 48
hr
 1569 840 0.3547 0.3996 0.5354 0.5238 1
Vemurafenib SKMEL28 3.1600
uM
 72
hr
 562 87 0.3563 0.3895 0.1548 0.1466 2
PLX-4720 MZ7-mel 3.1600
uM
 72
hr
 1016 159 0.3570 0.3290 0.1565 0.1506 3
Selumetinib COLO 858 1.0000
uM
 48
hr
 1935 372 0.3571 0.3740 0.1923 0.2319 2
AZ-628 MZ7-mel 3.1600
uM
 72
hr
 1240 382 0.3574 0.3266 0.3081 0.2930 4
PLX-4720 MZ7-mel 3.1600
uM
 72
hr
 1021 161 0.3582 0.3290 0.1577 0.1506 4
Selumetinib K2 0.3160
uM
 48
hr
 1058 75 0.3587 0.5403 0.0709 0.0691 4
Selumetinib MZ7-mel 0.3160
uM
 72
hr
 987 124 0.3595 0.3495 0.1256 0.1580 1
SB590885 MZ7-mel 3.1600
uM
 72
hr
 1019 155 0.3599 0.3870 0.1521 0.1433 1
AZ-628 COLO 858 0.3160
uM
 48
hr
 2005 429 0.3601 0.3684 0.2140 0.2211 2
Selumetinib SKMEL28 3.1600
uM
 72
hr
 623 143 0.3601 0.3372 0.2295 0.2145 2
Selumetinib SKMEL28 1.0000
uM
 72
hr
 543 63 0.3601 0.4189 0.1160 0.1114 3
Selumetinib K2 3.1600
uM
 48
hr
 1495 505 0.3613 0.5313 0.3378 0.3324 3
AZ-628 K2 1.0000
uM
 48
hr
 1405 415 0.3613 0.5963 0.2954 0.2538 4
Selumetinib K2 3.1600
uM
 24
hr
 752 137 0.3617 0.5493 0.1822 0.1419 3
AZ-628 MZ7-mel 0.1000
uM
 72
hr
 1029 159 0.3624 0.3362 0.1545 0.1557 3
SB590885 COLO 858 1.0000
uM
 72
hr
 1357 359 0.3625 0.3809 0.2646 0.2676 2
AZ-628 MZ7-mel 3.1600
uM
 72
hr
 1216 345 0.3628 0.3266 0.2837 0.2930 3
Selumetinib MZ7-mel 1.0000
uM
 72
hr
 1180 307 0.3637 0.3076 0.2602 0.2389 4