Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
Selumetinib K2 0.0100
uM
 48
hr
 2925 6 1.0653 0.9590 0.0021 0.0033 2
Selumetinib K2 0.0100
uM
 24
hr
 2285 6 1.3403 1.1449 0.0026 0.0032 1
Vemurafenib K2 0.1000
uM
 24
hr
 4584 6 2.6924 2.1002 0.0013 0.0017 1
K2 0.0000
uM
 48
hr
 2145 6 0.7806 0.0028 3
K2 0.0000
uM
 48
hr
 4249 6 1.5485 0.0014 2
K2 0.0000
uM
 48
hr
 3017 6 1.0988 0.0020 2
PLX-4720 K2 0.0316
uM
 48
hr
 3231 6 1.1769 1.1865 0.0019 0.0020 1
Vemurafenib K2 0.0032
uM
 48
hr
 3821 6 1.3923 1.4412 0.0016 0.0031 1
Selumetinib K2 0.0100
uM
 48
hr
 2248 6 0.8182 0.9590 0.0027 0.0033 1
AZ-628 K2 0.0032
uM
 24
hr
 2143 6 1.2568 1.2889 0.0028 0.0040 1
AZ-628 K2 0.0032
uM
 48
hr
 3287 6 1.1974 1.1976 0.0018 0.0026 1
Vemurafenib K2 0.0100
uM
 48
hr
 4070 6 1.4831 1.3424 0.0015 0.0026 3
PLX-4720 K2 0.0100
uM
 48
hr
 3201 7 1.1656 1.2705 0.0022 0.0022 1
SB590885 K2 0.0100
uM
 24
hr
 3633 7 2.1325 1.7957 0.0019 0.0024 2
AZ-628 K2 0.0100
uM
 48
hr
 2909 7 1.0591 1.0336 0.0024 0.0030 4
Vemurafenib K2 0.3160
uM
 24
hr
 3270 7 1.9191 1.5894 0.0021 0.0047 2
PLX-4720 MZ7-mel 0.0100
uM
 24
hr
 1137 7 0.8561 1.0212 0.0062 0.0082 3
Vemurafenib K2 0.0100
uM
 24
hr
 4147 7 2.4348 2.0827 0.0017 0.0023 2
SB590885 K2 0.0032
uM
 48
hr
 3865 7 1.4079 1.5110 0.0018 0.0019 1
PLX-4720 K2 0.0032
uM
 48
hr
 3223 7 1.1737 1.3444 0.0022 0.0024 2
MZ7-mel 0.0000
uM
 24
hr
 1415 7 1.0667 0.0049 1
K2 0.0000
uM
 24
hr
 3904 7 2.2919 0.0018 2
MZ7-mel 0.0000
uM
 24
hr
 1336 7 1.0068 0.0052 4
MZ7-mel 0.0000
uM
 24
hr
 1418 7 1.0689 0.0049 4
Vemurafenib K2 0.0316
uM
 48
hr
 3651 7 1.3299 1.3791 0.0019 0.0017 4