Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
Selumetinib K2 0.0032
uM
 48
hr
 3377 5 1.2306 1.1652 0.0015 0.0027 2
Vemurafenib K2 0.0316
uM
 24
hr
 2959 5 1.7373 2.1662 0.0017 0.0026 3
K2 0.0000
uM
 48
hr
 3119 5 1.1364 0.0016 3
Vemurafenib K2 0.0316
uM
 48
hr
 3967 5 1.4459 1.3791 0.0013 0.0017 3
SB590885 K2 0.0100
uM
 24
hr
 3664 5 2.1520 1.7957 0.0014 0.0024 1
SB590885 K2 0.0316
uM
 24
hr
 3898 5 2.2896 1.8176 0.0013 0.0022 2
K2 0.0000
uM
 24
hr
 1035 5 0.6058 0.0048 4
K2 0.0000
uM
 48
hr
 1736 5 0.6317 0.0029 4
K2 0.0000
uM
 24
hr
 2794 5 1.6403 0.0018 1
AZ-628 K2 0.0032
uM
 48
hr
 3396 5 1.2375 1.1976 0.0015 0.0026 2
K2 0.0000
uM
 24
hr
 2070 5 1.2145 0.0024 2
SB590885 K2 0.0032
uM
 48
hr
 4079 5 1.4868 1.5110 0.0012 0.0019 2
PLX-4720 MZ7-mel 0.0316
uM
 24
hr
 1662 5 1.2553 1.1367 0.0030 0.0100 2
AZ-628 K2 0.0100
uM
 24
hr
 1787 5 1.0480 1.4274 0.0028 0.0030 3
Selumetinib K2 0.0316
uM
 24
hr
 2368 5 1.3897 1.0203 0.0021 0.0045 2
Vemurafenib K2 0.1000
uM
 24
hr
 3143 5 1.8455 2.1002 0.0016 0.0017 3
SB590885 K2 0.0316
uM
 48
hr
 3564 6 1.2985 1.3782 0.0017 0.0017 2
Vemurafenib K2 0.1000
uM
 48
hr
 3765 6 1.3718 1.4312 0.0016 0.0023 4
K2 0.0000
uM
 24
hr
 1165 6 0.6816 0.0052 1
Selumetinib K2 0.0100
uM
 48
hr
 2248 6 0.8182 0.9590 0.0027 0.0033 1
SB590885 K2 0.0316
uM
 48
hr
 3871 6 1.4105 1.3782 0.0016 0.0017 4
Selumetinib K2 0.0100
uM
 24
hr
 2285 6 1.3403 1.1449 0.0026 0.0032 1
AZ-628 K2 0.0032
uM
 24
hr
 2143 6 1.2568 1.2889 0.0028 0.0040 1
PLX-4720 MZ7-mel 0.1000
uM
 24
hr
 1717 6 1.2962 1.1936 0.0035 0.0050 1
Vemurafenib K2 0.0100
uM
 48
hr
 4070 6 1.4831 1.3424 0.0015 0.0026 3