Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
PLX-4720 K2 0.0032
uM
 48
hr
 4064 15 1.4777 1.3444 0.0037 0.0024 3
PLX-4720 MZ7-mel 0.0032
uM
 24
hr
 1396 15 1.0462 1.0184 0.0107 0.0130 1
K2 0.0000
uM
 24
hr
 2276 15 1.3298 0.0066 1
Vemurafenib K2 0.0100
uM
 48
hr
 3320 15 1.2061 1.3424 0.0045 0.0026 2
WM-115 0.0000
uM
 48
hr
 226 15 0.4260 0.0664 4
Selumetinib K2 0.0316
uM
 48
hr
 2434 15 0.8828 0.8224 0.0062 0.0058 4
WM-115 0.0000
uM
 24
hr
 433 15 0.7983 0.0346 2
K2 0.0000
uM
 48
hr
 2258 15 0.8186 0.0066 2
PLX-4720 K2 0.0032
uM
 24
hr
 2556 15 1.4944 1.6766 0.0059 0.0050 4
SB590885 K2 1.0000
uM
 24
hr
 2523 15 1.4750 1.0860 0.0059 0.0129 1
MZ7-mel 0.0000
uM
 24
hr
 1366 16 1.0227 0.0117 2
PLX-4720 K2 0.0100
uM
 48
hr
 3482 16 1.2649 1.2705 0.0046 0.0022 4
Selumetinib K2 0.0316
uM
 48
hr
 2273 16 0.8237 0.8224 0.0070 0.0058 3
MZ7-mel 0.0000
uM
 48
hr
 3518 16 1.0842 0.0045 1
PLX-4720 K2 0.1000
uM
 48
hr
 2612 16 0.9474 0.8459 0.0061 0.0053 3
WM-115 0.0000
uM
 48
hr
 406 16 0.7874 0.0394 2
Vemurafenib MZ7-mel 0.0032
uM
 24
hr
 1426 16 1.0682 0.9820 0.0112 0.0137 2
AZ-628 MZ7-mel 0.0100
uM
 24
hr
 1280 16 0.9576 1.0178 0.0125 0.0129 3
MZ7-mel 0.0000
uM
 24
hr
 1135 16 0.8477 0.0141 4
PLX-4720 K2 0.1000
uM
 48
hr
 1925 16 0.6967 0.8459 0.0083 0.0053 4
Vemurafenib MZ7-mel 0.3160
uM
 24
hr
 1587 16 1.1902 1.1498 0.0101 0.0118 1
Selumetinib MZ7-mel 0.0316
uM
 24
hr
 1369 16 1.0250 1.1074 0.0117 0.0129 3
Vemurafenib K2 0.1000
uM
 48
hr
 4523 16 1.6448 1.4312 0.0035 0.0023 3
SB590885 K2 0.1000
uM
 48
hr
 4410 16 1.6036 1.4690 0.0036 0.0042 4
Vemurafenib MZ7-mel 0.3160
uM
 24
hr
 1867 16 1.4023 1.1498 0.0086 0.0118 2