Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
PLX-4720 MZ7-mel 1.0000
uM
 24
hr
 1048 14 0.7833 0.9557 0.0134 0.0127 4
MZ7-mel 0.0000
uM
 24
hr
 1371 14 1.0280 0.0102 3
Vemurafenib K2 0.3160
uM
 24
hr
 3379 14 1.9790 1.5894 0.0041 0.0047 1
Vemurafenib K2 0.0316
uM
 24
hr
 3350 14 1.9620 2.1662 0.0042 0.0026 4
PLX-4720 MZ7-mel 0.0032
uM
 24
hr
 1447 14 1.0856 1.0184 0.0097 0.0130 2
Vemurafenib K2 0.0032
uM
 24
hr
 3039 14 1.7791 1.7736 0.0046 0.0042 1
K2 0.0000
uM
 24
hr
 1714 14 0.9998 0.0082 2
SB590885 K2 0.3160
uM
 24
hr
 3041 14 1.7803 1.8941 0.0046 0.0035 4
PLX-4720 MZ7-mel 0.0100
uM
 24
hr
 1491 14 1.1189 1.0212 0.0094 0.0082 2
Vemurafenib WM-115 0.3160
uM
 24
hr
 469 14 0.8690 1.1741 0.0299 0.0444 1
Selumetinib K2 0.1000
uM
 24
hr
 750 14 0.4329 0.6297 0.0187 0.0128 3
AZ-628 K2 0.0032
uM
 48
hr
 3471 14 1.2616 1.1976 0.0040 0.0026 4
Vemurafenib K2 0.3160
uM
 24
hr
 2502 14 1.4633 1.5894 0.0056 0.0047 3
AZ-628 K2 0.1000
uM
 24
hr
 2345 14 1.3709 1.3258 0.0060 0.0060 1
PLX-4720 K2 0.0032
uM
 24
hr
 2556 15 1.4944 1.6766 0.0059 0.0050 4
K2 0.0000
uM
 24
hr
 2276 15 1.3298 0.0066 1
Selumetinib MZ7-mel 0.1000
uM
 24
hr
 1477 15 1.1076 1.0706 0.0102 0.0130 2
WM-115 0.0000
uM
 24
hr
 433 15 0.7983 0.0346 2
SB590885 K2 0.0100
uM
 48
hr
 4044 15 1.4704 1.3746 0.0037 0.0028 4
SB590885 K2 0.1000
uM
 48
hr
 3878 15 1.4098 1.4690 0.0039 0.0042 3
PLX-4720 K2 0.0032
uM
 48
hr
 4064 15 1.4777 1.3444 0.0037 0.0024 3
Vemurafenib WM-115 0.3160
uM
 24
hr
 439 15 0.8098 1.1741 0.0342 0.0444 2
MZ7-mel 0.0000
uM
 24
hr
 1351 15 1.0121 0.0111 3
WM-115 0.0000
uM
 24
hr
 448 15 0.8270 0.0335 4
WM-115 0.0000
uM
 48
hr
 226 15 0.4260 0.0664 4