Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
MZ7-mel 0.0000
uM
 24
hr
 1415 13 1.0621 0.0092 3
Vemurafenib K2 0.0316
uM
 24
hr
 4224 13 2.4766 2.1662 0.0031 0.0026 2
Selumetinib K2 0.0100
uM
 48
hr
 2849 13 1.0350 0.9590 0.0046 0.0033 4
Selumetinib K2 0.0032
uM
 24
hr
 2163 13 1.2645 1.1566 0.0060 0.0051 1
PLX-4720 K2 0.1000
uM
 24
hr
 3925 13 2.3008 1.4881 0.0033 0.0032 1
Selumetinib MZ7-mel 0.0032
uM
 24
hr
 1137 13 0.8515 1.0295 0.0114 0.0105 3
K2 0.0000
uM
 24
hr
 1375 13 0.8010 0.0095 2
Selumetinib K2 0.0316
uM
 48
hr
 2357 13 0.8554 0.8224 0.0055 0.0058 2
Selumetinib K2 0.1000
uM
 24
hr
 1055 13 0.6128 0.6297 0.0123 0.0128 1
K2 0.0000
uM
 24
hr
 1057 13 0.6140 0.0123 2
SB590885 MZ7-mel 0.0100
uM
 24
hr
 1338 13 1.0038 1.1830 0.0097 0.0117 4
AZ-628 MZ7-mel 0.0100
uM
 24
hr
 1046 13 0.7826 1.0178 0.0124 0.0129 4
MZ7-mel 0.0000
uM
 24
hr
 1322 13 0.9917 0.0098 2
Vemurafenib K2 0.0032
uM
 48
hr
 3938 13 1.4324 1.4412 0.0033 0.0031 2
Selumetinib MZ7-mel 0.0316
uM
 24
hr
 1257 13 0.9424 1.1074 0.0103 0.0129 4
MZ7-mel 0.0000
uM
 24
hr
 981 13 0.7333 0.0133 4
Vemurafenib MZ7-mel 0.0316
uM
 24
hr
 1321 13 0.9909 1.0795 0.0098 0.0072 4
Vemurafenib MZ7-mel 0.0316
uM
 24
hr
 1267 13 0.9500 1.0795 0.0103 0.0072 3
Vemurafenib K2 0.0032
uM
 24
hr
 2746 13 1.6074 1.7736 0.0047 0.0042 3
PLX-4720 K2 0.0100
uM
 24
hr
 3637 13 2.1314 1.7876 0.0036 0.0039 1
MZ7-mel 0.0000
uM
 24
hr
 1371 14 1.0280 0.0102 3
K2 0.0000
uM
 24
hr
 2809 14 1.6438 0.0050 3
AZ-628 K2 0.1000
uM
 24
hr
 2345 14 1.3709 1.3258 0.0060 0.0060 1
Vemurafenib WM-115 0.3160
uM
 24
hr
 469 14 0.8690 1.1741 0.0299 0.0444 1
K2 0.0000
uM
 24
hr
 1714 14 0.9998 0.0082 2