Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
Selumetinib C32 3.1600
uM
 48
hr
 1702 1393 0.1504 0.1270 0.8185 0.8303 4
Selumetinib C32 3.1600
uM
 48
hr
 1550 1314 0.1148 0.1270 0.8477 0.8303 2
AZ-628 MMAC-SF 3.1600
uM
 72
hr
 1255 798 0.1330 0.1411 0.6359 0.6202 4
AZ-628 MMAC-SF 3.1600
uM
 72
hr
 1481 953 0.1536 0.1411 0.6435 0.6202 3
AZ-628 MMAC-SF 3.1600
uM
 72
hr
 1164 698 0.1356 0.1411 0.5997 0.6202 1
AZ-628 MMAC-SF 3.1600
uM
 72
hr
 1228 739 0.1423 0.1411 0.6018 0.6202 2
Selumetinib MMAC-SF 3.1600
uM
 72
hr
 1255 743 0.1490 0.1414 0.5920 0.6168 2
Selumetinib MMAC-SF 3.1600
uM
 72
hr
 1276 842 0.1263 0.1414 0.6599 0.6168 3
Selumetinib MMAC-SF 3.1600
uM
 72
hr
 1143 638 0.1469 0.1414 0.5582 0.6168 1
Selumetinib MMAC-SF 3.1600
uM
 72
hr
 1438 945 0.1434 0.1414 0.6572 0.6168 4
PLX-4720 MMAC-SF 3.1600
uM
 72
hr
 1101 573 0.1536 0.1456 0.5204 0.5336 1
PLX-4720 MMAC-SF 3.1600
uM
 72
hr
 1019 565 0.1321 0.1456 0.5545 0.5336 2
PLX-4720 MMAC-SF 3.1600
uM
 72
hr
 1067 568 0.1452 0.1456 0.5323 0.5336 3
PLX-4720 MMAC-SF 3.1600
uM
 72
hr
 1102 581 0.1516 0.1456 0.5272 0.5336 4
PLX-4720 C32 3.1600
uM
 48
hr
 1504 1209 0.1435 0.1550 0.8039 0.7840 1
PLX-4720 C32 3.1600
uM
 48
hr
 1599 1210 0.1893 0.1550 0.7567 0.7840 4
PLX-4720 C32 3.1600
uM
 48
hr
 1321 1073 0.1207 0.1550 0.8123 0.7840 2
PLX-4720 C32 3.1600
uM
 48
hr
 1443 1101 0.1664 0.1550 0.7630 0.7840 3
Vemurafenib C32 1.0000
uM
 72
hr
 1158 676 0.2104 0.1615 0.5838 0.6577 3
Vemurafenib C32 1.0000
uM
 72
hr
 1089 716 0.1629 0.1615 0.6575 0.6577 4
Vemurafenib C32 1.0000
uM
 72
hr
 1032 733 0.1305 0.1615 0.7103 0.6577 2
Vemurafenib C32 1.0000
uM
 72
hr
 1017 691 0.1423 0.1615 0.6795 0.6577 1
AZ-628 C32 0.3160
uM
 72
hr
 1221 756 0.2030 0.1627 0.6192 0.6758 3
AZ-628 C32 0.3160
uM
 72
hr
 1236 861 0.1637 0.1627 0.6966 0.6758 4
AZ-628 C32 0.3160
uM
 72
hr
 1068 750 0.1388 0.1627 0.7023 0.6758 2