Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
PLX-4720 SKMEL28 3.1600
uM
 72
hr
 547 61 0.3646 0.3891 0.1115 0.1047 2
Vemurafenib SKMEL28 3.1600
uM
 72
hr
 630 95 0.4013 0.3895 0.1508 0.1466 4
Vemurafenib SKMEL28 3.1600
uM
 72
hr
 651 80 0.4283 0.3895 0.1229 0.1466 3
Vemurafenib SKMEL28 3.1600
uM
 72
hr
 562 87 0.3563 0.3895 0.1548 0.1466 2
Vemurafenib SKMEL28 3.1600
uM
 72
hr
 589 93 0.3721 0.3895 0.1579 0.1466 1
AZ-628 COLO 858 0.3160
uM
 72
hr
 1299 283 0.3690 0.3922 0.2179 0.2252 2
AZ-628 COLO 858 0.3160
uM
 72
hr
 1238 278 0.3487 0.3922 0.2246 0.2252 1
AZ-628 COLO 858 0.3160
uM
 72
hr
 1466 303 0.4224 0.3922 0.2067 0.2252 3
AZ-628 COLO 858 0.3160
uM
 72
hr
 1577 397 0.4286 0.3922 0.2517 0.2252 4
Vemurafenib COLO 858 1.0000
uM
 72
hr
 1660 441 0.4428 0.3928 0.2657 0.2502 3
Vemurafenib COLO 858 1.0000
uM
 72
hr
 1433 333 0.3996 0.3928 0.2324 0.2502 4
Vemurafenib COLO 858 1.0000
uM
 72
hr
 1495 369 0.4090 0.3928 0.2468 0.2502 1
Vemurafenib COLO 858 1.0000
uM
 72
hr
 1184 303 0.3200 0.3928 0.2559 0.2502 2
SB590885 C32 3.1600
uM
 48
hr
 1909 958 0.4627 0.3996 0.5018 0.5238 4
SB590885 C32 3.1600
uM
 48
hr
 1850 944 0.4408 0.3996 0.5103 0.5238 3
SB590885 C32 3.1600
uM
 48
hr
 1545 846 0.3401 0.3996 0.5476 0.5238 2
SB590885 C32 3.1600
uM
 48
hr
 1569 840 0.3547 0.3996 0.5354 0.5238 1
PLX-4720 COLO 858 1.0000
uM
 48
hr
 2238 304 0.4419 0.4070 0.1358 0.1839 2
PLX-4720 COLO 858 1.0000
uM
 48
hr
 2029 413 0.3692 0.4070 0.2036 0.1839 3
PLX-4720 COLO 858 1.0000
uM
 48
hr
 2445 635 0.4136 0.4070 0.2597 0.1839 4
PLX-4720 COLO 858 1.0000
uM
 48
hr
 2045 279 0.4035 0.4070 0.1364 0.1839 1
Selumetinib WM-115 1.0000
uM
 72
hr
 1778 642 0.3747 0.4086 0.3611 0.3021 1
Selumetinib WM-115 1.0000
uM
 72
hr
 1782 557 0.4041 0.4086 0.3126 0.3021 2
Selumetinib WM-115 1.0000
uM
 72
hr
 1691 446 0.4107 0.4086 0.2638 0.3021 3
Selumetinib WM-115 1.0000
uM
 72
hr
 1850 501 0.4450 0.4086 0.2708 0.3021 4